Appalachian College of Pharmacy Peripheral Cycloxygenase Inhibition Paper

Formulate a original response and then respond back to a classmate regarding this topic

Question: We generally consider acetaminophen to be “Safe” in most conditions (other than overdoses), and it dose not cause peripheral cycloxygenase inhibition – so thought to be an option for analgesia in asthma patients. There is a recent correlation of acetaminophen exposure and asthma. This got a significant amount of media attention and you will most likely receive questions

Come up with an original response to this topic using resources like pubmed to back up your claims. Site any sources used. Then respond back to this response by my classmate.

classmate response:

I think everyone has really hit it on the head, that the vast majority of these studies either show no difference between ibuprofen and acetaminophen in asthma development or exacerbations, or that there are too many confounders to allow for accurate results. The confounding variable that to me sticks out and negates really any of these studies is the fact that acetaminophen is typically the medication used for mild fever in children. Fever in children is commonly caused by mild viral infection, which when you consider that in itself is a common asthma trigger, it automatically is going to confound any results that come thereafter. So in my mind, what any positive results are showing is that parents rightfully give their children acetaminophen in the case of fever, but the viral infection has triggered existing yet unknown asthma. I suppose this leaves out those who gave their children acetaminophen for analgesia, but there are still so many confounders to account for that obtaining accurate results is difficult.

The only way to truly determine a relationship would be a large randomized controlled trial in which children with no previous history of asthma are exposed to acetaminophen and then followed for months/years to determine if there’s any difference between placebo group and treatment group.