PHAR 9926 Changes in PK parameters of drugs

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use attachments to help solve. here is the question:

Normal values for the pharmacokinetic parameters: clearance, fraction unbound in plasma, and fraction excreted unchanged are listed in Table below for Drugs A through G. Situations are presented that alter the kinetics of each of these drugs. On the right, indicate whether the value of each parameter would be observed to in-crease (↑), decrease (↓), or show little or no change (↔) and justify your answers. Each drug is administered orally and has a volume of distribution greater than 50 L

Purdue University Causes of Pelvic Pain and Its Symptoms Research Paper

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Pelvic pain can be acute or chronic and can be caused by any number of conditions. In primary care, nurse practitioners should be able to outline the basic approach to initial evaluation of and management of these disorders.

As you have learned in this unit there are many causes of pelvic pain. Select one of the causes of pelvic pain and describe the symptoms. Why and who would you refer this patient to for consultation? What are the steps to writing a referral and what is the NP’s responsibility for follow up?

No errors with APA 6th edition format.

Consistently uses Standard American English with no misspellings. Appropriate mechanics and formatting.

3 peer reviewed references

The post is at least 200 words.This does not include repeating the DB question or the citations and references.

Health assignment

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Project

This week you will review and answer the following case studies. Your answer should be at least one paragraph for each question answered and thoroughly address the topic. (30 points)

APA format

original work

Felicia

Felicia has been feeling tired recently. Her friend sells vitamin supplements through an online company, and she suggested Felicia start taking their energy formula to help her feel better. Felicia is interested, but she asks her friend to send her some information about the supplements before she buys them.

  1. What should she look for to help her evaluate the supplements?
  2. The Supplement Facts panel includes the following information for vitamins: Serving Size: 2 caplets Amount per serving % Daily Value Vitamin A 5000 IU 100% Vitamin C 200 mg 333% Vitamin D 600 IU 150% Vitamin E 30 IU 100% Vitamin K 80 mcg 100% Thiamin 50 mg 333% Riboflavin 50 mg 2941% Niacin 50 mg 250% Vitamin B6 150 mg 7500% Folic acid 600 mcg 150% Vitamin B12 12 mcg 200% Biotin 300 mcg 100% Pantothenic acid 20 mg 200%

If Felicia took 2 caplets per day, the recommended dose, is she likely to encounter any problems? If so, what problems might she encounter and which nutrients may cause them?

Fred

Fred is 69 and has always considered himself to be very healthy. He takes pride in the fact that he eats well and keeps physically and mentally fit with various voluntary activities in the community. Recently, his family has noticed that he seems rather lethargic, less coordinated than usual, and even a bit confused. He seems too young to be experiencing age-related cognitive deficits, so they are encouraging him to visit his doctor.

  1. Which vitamin deficiency could cause Fred’s cognitive problems? Why might he have developed this deficiency even though his eating habits have not changed?
  2. What could Fred do to reverse his deficiency?

Security Devices for Fire Protection to Personnel and Property

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The focus of this paper is the description of the chosen security device/s, the technology, and your explanation of how you would incorporate it/them into a specific security application. The paper should be one to three pages in length (excluding cover and references pages), in APA format, and a title and references page are required.

  1. Describe different types of alarm and fire sensor alarm systems.
  2. Explain the importance of having an effective fire protection system.

Security Concerns

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Expanded use of electronic health records and electronic storage of data has raised more security concerns for providers and for the patrons of medical care. Locate an article on the web or in our library, which indicates how security of patient data can be improved and assured. Indicate one security feature you would want to see included in the information plan for a facility you might work for in the future, such as a hospital or physician’s office. Explain why you’d want that particular feature.

250 Word minimum

APA Format

Come up with responses to my classmates forum postes

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These are all on the same topic. I just have to formulate different responses to my classmates forum posts. These are what they wrote. find articles relating to what they wrote and ask them a question to respond to to promote discussion. Here is the original question that was asked. Come up with a paragraph response and be sure to ask them a question back.

Original question asked: Group G students will be responsible for utilizing tertiary, secondary and primary literature for initiating and answering the following questions about nephrolithiasis (kidney stones) What is in current lay literature and newspapers regarding Kidney stones?

Come up with a different formulated response to these classmates forum posts

classmate 1: Bre

Primary literature regarding nephrolithiasis

I found a 5-year randomized prospective study. The aim of the study was to see how much of a risk urine volume factors in patients nephrolithiasis was. They took 199 patients who had already had one idiopathic calcium stone. They randomly split the participants into two groups and followed them for five years. One group was a controlled group and the other was involved in a high intake of water. The patients were evaluated every year for five years. They concluded from their study that increasing your urine volume can decrease the prevalence of kidney stones. They also believe that taking in more water should be the first line therapy in preventing future occurrences. In the 5-year time frame 12 participants in the experimental group had another episode involving kidney stones. The control group had 27 participants who had another kidney stone. I would like to see the study done with much more participants in each group, which I think could be possible. It is an easy study to replicate and doesn’t involve much risk to the participants. It makes sense from a physiology standpoint that more water intake would help with preventing kidney stones. Drinking more water ultimately dilutes the substances in your urine that could cause a stone. I also think dietary changes should be involved with the increase in water intake, an example would be to cut out things that could dehydrate the body, such as caffeine.

Reference:

Borghi L, Meschi T, Amato F, Briganti A, Novarini A, Giannini A. Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study. J Urol. 1996 Mar;155(3):839-43.

Secondary literature regarding nephrolithiasis

The article I found while researching was very insightful. Kidney stones are rising in the United States every year and is already affecting a little over five percent of adults in America. Out of all the chronic kidney conditions nephrolithiasis is 2nd most common under hypertension. Something I found interesting was that kidney stones are more common in men than in woman. Since I have been married to my wife, she has had kidney stones twice, and it was tough to see her go through it. I know of multiple woman in her family who also are prone to getting kidney stones. This has been my only exposure to kidney stones, personally so it came as a surprise that it is more prevalent in men than woman, because I have only had women in my life experience them. The article also went into the difference between the stones in woman and men because there is a difference in the composition of the two. The composition also differs in children.

Classmate 2: Sha

Primary Literature – I found a prospective study which included the health professional follow-up study (HPFS), nurse’s health study (NHS1), nurse’s health study (NHS2). The study explored the association between history of kidney stones and risk of coronary heart disease. The study was conducted between 1986-2010 with 242,105 people: men(45,748), women(196,357). The men were followed for 24 years and the women for 18 years. At the conclusion of the study, 19,678 people reported kidney stones. The study showed no significance association in the men. However, in the female group a history of kidney stones did show an increased risk of coronary artery disease.

JAMA. 2013 Jul 24; 310(4): 408–415. doi: 10.1001/jama.2013.8780 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC40199…

Secondary Literature – I found a meta-analysis and systematic review of cohort studies that measured kidney disease and its association with diabetes, obesity, waist circumference, BMI, and physicial activity. The review searched PumMed and Embase up until 4/22/2018 for the studies and it consisted of cohorts with specific relationships. BMI and kidney stones (8 cohorts); waist circumference and kidney stones (5 cohorts); weight gain and kidney stones (3 cohorts); diabetes and kidney stones (10 cohorts); physical activity and kidney stones (4 cohorts). The review observed as of lately kidney, stones have been associated with heart disease. Since heart disease is associated with obesity and diabetes it makes sense to explore the possible connection that kidney stones could have the same risk factors. The study found that several reports of increased body mass index, greater waist circumference, weight gain and diabetes were associated with kidney stones. Eur J Epidemiol. 2018;33(11): 1033-1047

references: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC62089…

Tertiary Literature – I found a newsletter (reviewed by Univ of Illinois-Chicago, School of Medicine) from Medical News Today entitled, “How do you get kidney stones?”. Kidney stones are caused by calcification and build-up of certain materials inside the kidneys. Kidney stones form as a result of low water intake. When we don’t drink enough water to sufficiently dilute the urine, the urine becomes very acidic and form kidney stones. The newsletter reports that more men than women suffer from kidney stones and the average age is 30-50 in both. If you have a family history of kidney stones, you have a greater risk to develop kidney stones. To me, the newsletter echoes the same sentiment as the primary and secondary literature I read regarding certain risk factors. People who eat high protein and high sodium foods, have very little physical activity, are obese, and have hypertension are at much high risk to have kidney stones. https://www.medicalnewstoday.com/articles/154193.p…

classmate 3 ze
According to several articles, kidney stones are most commonly described as minerals and salts that form into hard deposits in your kidneys. There are several types of kidney stones calcium stones, cysteine stones, struvite stones and uric acid stones.

Calcium stones are the most common type of kidney stone and they have been linked to consuming foods with high oxalate content, metabolic conditions, medications such as topiramate and high doses of vitamin d. Cystine stones are the least common type of kidney stones, they are formed by too much cystine in the urine. Struvite stones are typically linked to people that get chronic urinary tract infections. The last type of stones are uric acid stones. Having a diet high in animal protein, being overweight, having gout and being diabetic may result in Uric acid stones.

One of the biggest risk factors for all types of kidney stones is dehydration. Having concentrated urine makes it more likely for stones to form. Increasing your fluid intake will dilate the urine and help keep salts dissolved.

The following medications have been known to help patients with kidney stones –thiazide diuretics, allopurinol, potassium citrate, acetohydroxamic acid and cysteine binding drugs.

Most kidney stones are passed without any type of treatment, however depending on the severity of the stone surgery may be necessary.

NUR3050 Nova Southeastern Pediatric Palliative Care Quantitative Critique

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Assignment Criteria:

Develop a scholarly paper that addresses the following criteria:

1.Identify an area of clinical interest.

2.Find a minimum of one peer-reviewed journal article (no older than 5 years) related to your clinical topic of interest. Do not use a meta-analysis or systematic review (Article is provided in the document attached below, no need extra articles).

3.Critique the journal article, fully answering the questions in the provided document.

  • The scholarly paper should be in narrative format, 4 to 5 pages excluding the title and reference page.
  • Includean introductory paragraph, purpose statement, and a conclusion.
  • Include level 1 and 2 headings to organize the paper.
  • Write the paper in third person, not first person (meaning do not use ‘we’ or ‘I’) and in a scholarly manner. To clarify: I, we, you, me, our may not be used. In addition, describing yourself as the researcher or the author should not be used.
  • Include a minimum of one professional peer-reviewed scholarly journal references to support the paper and a second benchmark peer reviewed source (may be textbook or other journal article)and be less than five (5) years old.
  • APA format is required (attention to spelling/grammar, a title page, a reference page, and in-text citations).

4-5 pages not including cover and reference pages

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You have been invited to do a presentation to the laboratory department regarding Health Insurance Portability and Accountability Act (HIPAA) compliance and electronic health records. Discuss the salient points of your presentation and why you feel it is important to include this information in your presentation.

Include the following information:

  • Define protected health information and when it can be disclosed.
  • Differentiate between the privacy rule and the security rule as it applies to actual use in the laboratory.
  • Differentiate between identifiable and unidentified information and their uses.

What is stress and what is pain?

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Take the role of a mental health professional invited to give a presentation on stress management. Identify a target audience (e.g.,, children, adolescents, adults) and any relevant demographics (e.g., ethnicity, age ranges, sexual orientation, religion, etc.) and other characteristics unique to your target population (e.g., older adults, military spouses, children of divorce, newlywed couples, living in a high crime area, unemployed for more than a year, victims of bullying, excessive parental pressure to achieve, etc.). The primary stressors experienced by your target population can be due to positive and/or negative life events. Research effective strategies for coping with stressors and skills to develop resilience. You will use the information from your research to examine uses and applications of applied behavioral science to stress and coping interventions and identify current trends in how applied behavioral science is used to develop resilience.
Create a written summary of the information you would include in a presentation on the assigned topic.

Required topics to be addressed: Your summary must cover each of the following topics in the order presented below in your own words. Be sure to write in complete sentences.

  • Identify specific characteristics of your target audience.
  • Briefly define stress and give examples relevant to your target audience.
  • Discuss at least two specific stressors relevant to your target audience’s primary concerns.
  • Describe healthy and unhealthy ways in which people may respond to the two stressors listed in #3 above.
  • Select one specific skill a mental health professional might teach to help individuals cope effectively with stress.
  • Define resilience and identify at least three factors associated with resilience.
  • Identify at least three ways to build resilience.
  • Discuss the importance of flexibility in maintaining resilience.
  • List at least one online, print, video, and/or local resources in your community where participants may receive additional help in learning to effectively cope with life stressors and develop/enhance their resilience skills.

Be sure to include in-text citations and a reference list that are in accordance with APA style as outlined in the Ashford Writing Center (Links to an external site.)Links to an external site.. For further assistance in researching scholarly sources, be sure to access the tutorials page on the Ashford University Library website.