Linda has been tired and complains of feeling weak for the last two to three months. Blood work shows that she has folic acid deficiency anemia. The code(s) for this case are _____________.

1. For the statement “ovarian androgen hormone hypersecretion” the main term to reference in the Index is __________.

[removed]

a.

ovarian

[removed]

b.

androgen

[removed]

c.

hormone

[removed]

d.

hypersecretion

QUESTION 2

1. For the statement “oligospermia due to efferent duct obstruction” the main term to reference in the Index is __________.

[removed]

a.

oligospermia

[removed]

b.

efferent

[removed]

c.

duct

[removed]

d.

obstruction

QUESTION 3

1. For the statement “acute antitubular basement membrane nephritis” the main term to reference in the Index is __________.

[removed]

a.

antitibular

[removed]

b.

basement

[removed]

c.

membrane

[removed]

d.

nephritis

QUESTION 4

1. For the statement “adhesive shoulder joint capsulitis” the main term to reference in the Index is ___________.

[removed]

a.

adhesive

[removed]

b.

shoulder

[removed]

c.

joint

[removed]

d.

capsulitis

QUESTION 5

1. Acute adenoviral follicular conjunctivitis is reported with code(s) _____________.

[removed]

a.

B30

[removed]

b.

B30.1

[removed]

c.

B30.1, H10.9

[removed]

d.

B30.9

QUESTION 6

1. Viral endocarditis is reported with code(s) __________.

[removed]

a.

B33.21, I38

[removed]

b.

B33.24, I38

[removed]

c.

B33.24

[removed]

d.

B33.21

QUESTION 7

1. Mast cell leukemia in remission is reported with code ___________.

[removed]

a.

C94.3

[removed]

b.

C94.30

[removed]

c.

C94.31

[removed]

d.

C94.32

QUESTION 8

1. Evans syndrome is reported with code __________.

[removed]

a.

D69

[removed]

b.

D69.4

[removed]

c.

D69.41

[removed]

d.

D69.49

QUESTION 9

1. Medullary hypoplasia is reported with code ___________.

[removed]

a.

D61.9

[removed]

b.

D61.1

[removed]

c.

D62

[removed]

d.

D63.8

QUESTION 10

1. Tommy Jones was hospitalized, and the discharge diagnosis recorded for his case is meningitis due to Lyme disease. The correct code(s) for this case is/are __________.

[removed]

a.

A69.20

[removed]

b.

A69.20, G03.9

[removed]

c.

G03.9

[removed]

d.

A69.21

QUESTION 11

1. Malignant neoplasm of the tail of the pancreas is reported with code __________.

[removed]

a.

C24.9

[removed]

b.

C25

[removed]

c.

C25.2

[removed]

d.

C26.9

QUESTION 12

1. Sally was admitted with a mass on her left ovary. After work-up it was determined that the mass was a benign neoplasm. The correct code for the principal diagnosis is __________.

[removed]

a.

R19.01

[removed]

b.

D26.0

[removed]

c.

D27.1

[removed]

d.

R19.00

QUESTION 13

1. Tuberculosis cerebral arteritis is reported with code _____________.

[removed]

a.

I77.6

[removed]

b.

A18.89

[removed]

c.

M31.6

[removed]

d.

A18.85

QUESTION 14

1. Scarlet fever with otitis media is reported with code __________.

[removed]

a.

A38.9

[removed]

b.

A38.1

[removed]

c.

A38.0

[removed]

d.

A38.8

1. Tom Jones is being seen today by Dr. Smith for gonococcal tenosynovitis. The correct code for this case is _____________.

[removed]

a.

A54.49

[removed]

b.

M65.9

[removed]

c.

A54.42

[removed]

d.

A54.4

QUESTION 16

1. Tim Hill has been experiencing diarrhea for a number of weeks with weight loss. Testing has determined that he has a beef tapeworm infection. Code(s) ________________________ would be reported for this case.

[removed]

a.

R19.7

[removed]

b.

R19.7, B68.1

[removed]

c.

B68.1

[removed]

d.

B71.9

QUESTION 17

1. The code used to report a benign neoplam of ureteric orifice of bladder is ____________.

[removed]

a.

D30.3

[removed]

b.

C67.6

[removed]

c.

C67.5

[removed]

d.

D30

QUESTION 18

1. A benign neoplasm of the hepatic flexure is coded with code ____________.

[removed]

a.

C18.3

[removed]

b.

D12.3

[removed]

c.

D12

[removed]

d.

D12.9

QUESTION 19

1. Janet is an 84 year old complaining of being tired and weak for the last week. She drove herself to the emergency department. The provided ordered blood work-up that revealed mast cell leukemia. The diagnostic code to report for this encounter is _____________.

[removed]

a.

C94.32

[removed]

b.

C94.31

[removed]

c.

C94

[removed]

d.

C94.30

QUESTION 20

1. Linda has been tired and complains of feeling weak for the last two to three months. Blood work shows that she has folic acid deficiency anemia. The code(s) for this case are _____________.

[removed]

a.

R53.1

[removed]

b.

R53.1, D52.9

[removed]

c.

D52.9

[removed]

d.

D52.0

Explain which therapeutic approach you might use with clients and why. Support your approach with evidence-based literature.

Assignment: Supportive Psychotherapy

versus

Interpersonal Psychotherapy

Although supportive psychotherapy and interpersonal psychotherapy share some similarities, these therapeutic approaches have many differences. When assessing clients and selecting therapies, it is important to recognize these differences and how they may impact your clients. For this Assignment, as you compare supportive and interpersonal psychotherapy, consider which therapeutic approach you might use with your clients.

.

The Assignment

In a 1- to 2-page paper, address the following:

· Briefly describe how supportive and interpersonal psychotherapies are similar.

· Explain at least three differences between these therapies. Include how these

differences might impact your practice as a mental health counselor.

· Explain which therapeutic approach you might use with clients and why. Support

your approach with evidence-based literature.

· PLEASE DO NOT FAIL TO INCLUDE INTRODUCTION, CONCLUSION, AND WITH

REFERENCES

Learning Resources

Required Readings

Wheeler, K. (Ed.). (2014). Psychotherapy for the advanced practice psychiatric nurse: A how-to guide for evidence-based practice (2nd ed.). New York, NY: Springer Publishing Company.

Chapter 5, “Supportive and Psychodynamic Psychotherapy” (pp. 238–242)

Chapter 9, “Interpersonal Psychotherapy” (pp. 347–368)

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.

Abeles, N., & Koocher, G. P. (2011). Ethics in psychotherapy. In J. C. Norcross, G. R. VandenBos, D. K. Freedheim, J. C. Norcross, G. R. VandenBos, & D. K. Freedheim (Eds.), History of psychotherapy: Continuity and change (pp. 723–740). Washington, DC: American Psychological Association. doi:10.1037/12353-048

Cameron, S., & Turtle-Song, I. (2002). Learning to write case notes using the SOAP format. Journal of Counseling and Development, 80(3), 286–292. Retrieved from the Academic Search Complete database. (Accession No. 7164780)

Nicholson, R. (2002). The dilemma of psychotherapy notes and HIPAA. Journal of AHIMA, 73(2), 38–39. Retrieved from http://library.ahima.org/doc?oid=58162#.V5J0__krLZ4http://library.ahima.org/doc?oid=58162#.V5J0__krLZ4

U.S. Department of Health & Human Services. (n.d.). HIPAA privacy rule and sharing information related to mental health. Retrieved from http://www.hhs.gov/hipaa/for-professionals/special-topics/mental-health/

Required Media

Sommers-Flanagan, J., & Sommers-Flanagan, R. (2013). Counseling and psychotherapy theories in context and practice [Video file]. Mill Valley, CA: Psychotherapy.net.

Stuart, S. (2010). Interpersonal psychotherapy: A case of postpartum depression [Video file]. Mill Valley, CA: Psychotherapy.net

How are your two comparison groups different, as they are currently stated the groups seem very much the same, could you state, standard care instead of pre and post intervention assessments?

10 Strategic Points for the Prospectus, Proposal, and Direct Practice Improvement Project

Week Two Assignment Instructions DNP 820

Please read the instructions thoroughly there are strict requirements

I need at least 10 different articles/literature reviews added to the ones in the 815 attachment. I have also included the chart to be filled out All within 5 years and pertinent to the subject.

Tutor MUST have a good command of the English language

The Rubric must be followed, and all the requirements met

This is a thorough professor, and she has strict requirements

I have attached the PICOT and the first 10 points (DNP 815) assignment. This is a continuation of that assignment. Please read the attachments

The following needs to be addressed:

Please note the followings: The introduction and the literature review are complete and thorough. The problem statement is written clearly PICOT is clear and very good Sample:

· How will you determine the sample size?

· What are the inclusion/exclusion criteria of the subjects? Methodology: Why is the selected methodology is appropriate? Please justify!

· Data collection approach needs to be clear. How will you collect your data? What is needed here is to describe the process of collecting data form signing the informed consent until completing the measuring.

· Data analysis-What test will you use to answer your research question?

Clinical/PICOT Questions:

“In adult patients with CVC at a Clear Lake Regional Medical Center, does interventional staff education about hub hygiene provided to RN’s who access the CVC impact CLABSI rates compared to standard care over a one-month period?”

P: Patients with Central Venous Catheters

I: Staff re-education related to Hygiene of the hub

C: Other hospitals

O: Reduce probability of CLABSIs

T: Two months

“In Patients > 65 years of age with central line catheters at a Clear Lake Regional Medical Center, how does staff training of key personnel and reinforcement of central line catheter hub hygiene after its insertion, along with the apt cleansing of the insertion site, before every approach compared with other area hospitals, reduce the incidence of CLABSIs (Central Line Associated Blood-stream Infections) over a one-month period?”

P: Patients > 65 years of age with a Central line

I: Staff training and reinforcement of Central Catheter, Hub Hygiene

C: Other area hospitals

O: Reduce probability of CLABSIs

“In adult patients, with define CVC (CVC), does interventional staff education about hub hygiene provided to RN’s who access the CVC impact CLABSI rates compared to pre and post-intervention assessments

1. I used central Missouri as an example, replace with a description of your site.

2. While you might be interested in CLASBI rates as a primary variable, there are other patient outcomes that would also be important to consider

3. Ensure you can find validity and reliability measures on CLASBI rates if you cannot, we need to determine another question to help

4. How are your two comparison groups different, as they are currently stated the groups seem very much the same, could you state, standard care instead of pre and post intervention assessments?

5. One month is the longest time you can use for a prospective project

Please note the following regarding the instructors grading

IMPORTANT INFORMATION ABOUT MY GRADING STYLE

As you prepare for written papers and manuscripts I’d like to give you some details about my grading style. I provide significant feedback on your papers, this is because I believe you should be working towards improving your writing so that at the end of this program you are able to successfully write your DPI project. In order to write well, you need feedback and you need to review that feedback and make progress on the next written work. To that end I always grade accordingly. This means that if I provide feedback one an item (for example APA format of your reference page) I expect that this will be improved on the next written submission. Otherwise I will deduct additional points. In addition, some other criteria to get down pat now. References should always

1. Be current, no older than 5 years that means 5 years from your proposed graduation date (2014-2019). Otherwise you will have to redo everything in DNP 955.

2. Be primary sources. You can no longer cite Young declared literary war in 1956 (as cited by Brown 2006). You must cite Young 1956. That means go find that paper and read it and make sure that you agree with what Brown said. What if you don’t agree due to some very valid points? Then the literary war is not what occurred, but instead you have concerns regarding point ____, ____, and ____.

3. You may no longer cite textbooks, they are 1) secondary sources and 2) not current enough, and please use peer reviewed manuscripts.

One more item that is not a reference. You may not use direct quotes any longer. There is no need. This may be difficult at first, but you are moving towards a different type of writing. This is manuscript writing (scientific writing). Scientific writing is terse, clear, and concise. No frilly words. In order to avoid the use of direct quotes you will synthesize the literature. There is a great resource for synthesizing the literature under Resources – Add-ons. These are also some other great writing resources there.

Details:

In the prospectus, proposal, and scholarly project there are 10 strategic points that need to be clear, simple, correct, and aligned to ensure the research is doable, valuable, and credible. The 10 strategic points emerge from researching literature on a topic that is based on or aligned with the learner’s personal passion, future career purpose, and degree area. These 10 points provide a guiding vision for DPI Project. In this assignment, you will continue the work begun in DNP-815, working on your draft of a document addressing the 10 key strategic points that define your intended research focus and approach.

General Requirements:

Use the following information to ensure successful completion of the assignment:

Locate the “The 10 Strategic Points for the Prospectus, Proposal, and Direct Practice Improvement Project” that you completed in DNP-815.

Doctoral learners are required to use APA style for their writing assignments. The APA Style Guide is located in the Student Success Center. An abstract is not required.

This assignment uses a rubric. Please Review the rubric prior to the beginning to become familiar with the expectations for successful completion.

You are required to submit this assignment to Turnitin. Please refer to the directions in the Student Success Center.

Which of the following will the nurse include in an explanation?

Question 1 A patient asks the nurse practitioner about food sources such as soybeans and soy products. The nurse practitioner understands that these foods are considered

A) phytoestrogens.

B) monotherapy.

C) taboo.

D) inappropriate

Question 2 A 12-year-old boy is being discharged from the hospital after major surgery. The boy will be taking two medications at home for an extended period. The nurse who is discharging the patient should provide medication teaching specifically to

A) the mother regarding why the boy needs to take the medications.

B) both the boy and his mother regarding all medication issued.

C) the boy by telling him not to worry about the medications and to take them as directed

D) The mother and be sure to reinforce the need to force the medications, if her sondoes not want to take them

Question 3 A 15-year-old boy who has been taking dextroamphetamine for the treatment of ADHD has been experiencing a depressed mood and a sense of hopelessness. He confides in the school nurse that he has begun taking his stepfather’s antidepressant to improve his mood. After immediately phoning the boy’s stepfather, the nurse learns that the drug in question is phenelzine (Nardil), a monoamine oxidase inhibitor (MAOI). The nurse should recognize that this combination of drugs creates a serious risk of what health problem?

A) Cardiac dysrhythmia

B) Hypertensive crisis

C) Nephrotoxicity

D) Hypokalemia

Question 4 A child is admitted to the burn unit with second and third degree burns on both arms and part of his or her face. When administering topical medications to the burned areas, the nurse should

A) cool the medication prior to administration.

B) use sterile technique when applying the medication.

C) allow the child to apply the medication if possible.

D) use clean technique only when applying the medication.

Question 5 A patient is being seen in the emergency department for a sprained ankle and is given a drug to relieve pain. When a second dose of the pain medication is given, the patient develops redness of the skin, itching, and swelling at the site of injection of the drug. The most likely cause of this response is

A) a hepatotoxic response.

B) an idiosyncratic response.

C) a paradoxical response.

D) an allergic response.

Question 6 A 5-year-old boy needs an IM injection. The least painful and most effective injection site would be the

A) deltoid muscle.

B) rectus femoris muscle.

C) ventrogluteal muscle.

D) dorsogluteal muscle.

Question 7 A patient reports to a clinic with complaints of breast tenderness, a right lumpy breast, and no breast discharge. The breast tenderness occurs primarily during her menstrual cycle. The nurse practitioner probably suspects

A) breast cancer

B) PMS

C) pain in the heart

D) cancerous breast tenderness

Question 8 A 29-year-old woman who is morbidly obese has recently begun a comprehensive, medically-supervised program of weight reduction. Prior to adding dextroamphetamine (Dexedrine) to her regimen, the patient should be questioned about her intake of

A) alcohol.

B) trans fat.

C) caffeine.

D) grapefruit juice.

Question 9 A nurse is caring for a 10-year-old boy who complains of chronic headaches. His mother reports that she gives him Tylenol at least three times a day. Which of the following will the nurse work with the physician to evaluate?

A) Renal function

B) Hepatic function

C) Respiratory function

D) Cardiac function

Question 10 A 21-year-old female has a history of irregular menses. She recently became sexually active, and would like to begin taking oral contraceptives (OCs). The nurse practitioner recognizes that most likely this patient would benefit from taking which category of OCs.

A) Monophasic

B) Triphasic OC

C) Ortho Tri-Cyclen

D) Biphasic OC

Question 11 A nurse who provides care on a pediatric medicine unit has conducted a medication reconciliation of a recently-admitted patient. In light of the fact that the child takes methylphenidate (Ritalin), the nurse is justified in considering a history of what health problem?

A) Anxiety

B) Respiratory depression

C) Obesity

D) ADHD

Question 12 A nurse working in a cancer center is preparing to administer medication to a 5-year-old child. The nurse will calculate the drug dosage by using

A) body surface area.

B) weight.

C) age in months.

D) age in years.

Question 13 A 13-year-old female took a weight loss drug that activated the sympathetic nervous system. Which of the following assessment findings would the nurse expect?

A) Decreased myocardial contraction

B) Decreased heart rate

C) Increased cardiac conduction

D) Increased intranodal conduction time

Question 14 A 6-month-old child has developed skin irritation due to an allergic reaction. He has been prescribed a topical skin ointment. The nurse will consider which of the following before administering the drug?

A) That the infant’s skin has greater permeability than that of an adult

B) That there is less body surface area to be concerned about

C) That there is decreased absorption rates of topical drugs in infants

D) That there is a lower concentration of water in an infant’s body compared with an adult

Question 15 A nurse is providing patient education to a 13-year-old girl who was just diagnosed with type 1 diabetes mellitus. Which of the following statements by the patient will alert the nurse that special instructions regarding insulin are necessary?

A) “I walk two blocks to school every day.”

B) “I am on the middle school track team.”

C) “We live in a two-story house.”

D) “My mother is going to give me my insulin.”

Question 16 A nurse who provides care on a pediatric unit of a hospital is aware that the potential for harm as a result of drug errors is higher among infants and children than adults. This fact is primarily due to

A) the inability of infants and children and describe symptoms of adverse drug reactions.

B) increased body surface area relative to body volume in infants and children.

C) increased heart rate and subsequently rapid drug distribution among infants and children.

D) immature liver and kidney function in infants and children.

Question 17 A nurse practitioner orders 150 mg of oral fluconazole for a patient with vulvovaginal candidiasis. The patient should expect to take medication

A) for 20 days.

B) once a day.

C) every day until the infection is gone.

D) for 30 days.

Question 18 To which of the following patients would a medication nurse most likely administer caffeine as part of the treatment plan?

A) A preterm neonate who has apnea

B) A 34-year-old woman with a diagnosis of gastric ulcerations

C) A school-age child with severe ADHD

D) A 52-year-old man with narcolepsy

Question 19 A nurse works at a weight management clinic. To which of the following overweight patients could the nurse safely administer dextroamphetamine?

A) A 38-year-old Caucasian woman with glaucoma

B) A 60-year-old African-American man who experiences angina

C) A 48-year-old Caucasian man who has adult-onset diabetes

D) A 28-year-old African-American woman with hyperthyroidism

Question 20 A 3-year-old boy has developed otitis media and requires antibiotics. In order to increase the chance that the boy will take his prescribed medication, the nurse should

A) teach the boy about the fact that he will feel much better after he takes his medications.

B) have the mother hold the child firmly and sooth him while the drugs are administered.

C) offer a choice between liquid and chewable medications, if possible.

D) insert a central intravenous line.

Question 21 The recommended treatment for trichomoniasis is

A) Flagyl.

B) Diflucan.

C) Meclizine.

D) Amoxicillan

Question 22 A school nurse has been teaching high school students about the risks associated with marijuana use. However, the nurse has been met with considerable skepticism on the part of students, most of whom believe that marijuana is a benign drug. Which of the following teaching points should the nurse provide?

A) “Most people don’t know that marijuana can be just as addictive as heroin or cocaine over time.”

B) “Marijuana can easily interact with other drugs and cause potentially fatal reactions.”

C) “Every year, thousands of Americans end up in emergency departments with marijuana overdoses.”

D) “Smoking marijuana is just as bad, or worse, for your lungs as smoking cigarettes.”

Question 23 A nurse is going to administer medication to an infant using a medicine dropper. The best method is to open the child’s mouth by gently squeezing the cheeks and placing the drops

A) at the back of the mouth.

B) in the buccal pouch.

C) under the tongue.

D) on top of the tongue.

Question 24 A nurse is obtaining baseline physical data from a 7-year-old patient who is to be started on dextroamphetamine for ADHD. After obtaining vital signs, height, and weight, the nurse will prepare the patient for an

A) electrocardiogram (ECG).

B) electromyelogram (EMG).

C) electroencephalogram (EEG).

D) electrophysiologic study (EPS).

Question 25 A 10-year-old boy is taking dextroamphetamine (Dexedrine) daily for ADHD. At each clinic visit, the nurse’s priority assessment would be

A) height and weight.

B) Vision.

C) body temperature.

D) blood pressure.

Question 26 A 7-year-old child has been taking tetracycline for a bacterial infection. The nurse will be sure to inform the parents that this drug could cause

A) orange-tinged urine.

B) staining of permanent teeth.

C) sleep deprivation.

D) deep muscle pain.

Question 27 A nurse is administering drugs to a 10-year-old child who has multiple health problems.The child is underweight and is on a special diet. Which of the following will the nurse consider when planning for the best absorption of the prescribed drugs? (Select all that apply.)

A) Age

B) Weight

C) Disease process

D) Diet

E) Route of administration

ACDE

Question 28 The clinical nurse educator who oversees the emergency department in a children’s hospital has launched an awareness program aimed at reducing drug errors. What measure addresses the most common cause of incorrect doses in the care of infants and children?

A) Having nurses check their math calculations with a colleague before administering a drug.

B) Ensuring that a full assessment takes place no more than 30 minutes before giving a drug.

C) Recording drug administration in both the nurse’s notes and the medication administration record (MAR)

D) Avoiding intravenous administration of drugs whenever possible.

Question 29 A 15-year-old boy has been diagnosed with bone cancer after several months of fatigue and pain. What question should the nurse include in an assessment when trying to minimize the potential for adverse drug reactions?

A) “Do you ever use alcohol or drugs?”

B) “How much do you weigh?”

C) “On a scale of zero to ten, what level of pain is acceptable to you?”

D) “Did Tylenol or other over-the-counter pain remedies ever relieve your pain?”

Question 30 A 35-year-old woman is on a weight-loss program and is to begin taking sibutramine (Meridia). After baseline physical data are obtained, the nurse will assess the patient’s childbearing potential. The nurse will inform the patient that during sibutramine therapy she should

A) abstain from sex.

B) obtain a pap smear .

C) use adequate contraception.

D) take a pregnancy test every month.

Question 31 A 16-year-old boy is prescribed cromolyn sodium nasal spray to treat a nasal allergy. To maximize the therapeutic effects of the drug, which of the following will the nurse include in instructions to the patient?

A) Take the drug on a full stomach

B) Avoid high noise levels

C) Take the drug for one full week before coming in contact with allergens

D) Drink plenty of fluids.

Question 32 A 19-year-old patient reports to a clinic with vaginal discharge with a foul odor. A microscopic exam reveals trichomonas vaginalis.The nurse practitioner is aware that

A) trichomoniasis is an incurable disease.

B) trichomoniasis discharge is typically thin and clear.

C) asymptomatic women are diagnosed with trichomoniasis by a routine pap smear.

D) it is unusual to have an odor with trichomoniasis

Question 33 A 2-year-old child is diagnosed with a minor ailment and is to be administered medications at home for 2 weeks. The child lives with his mother, grandmother, and four other children between the ages of 14 months and 7 years. The home health nurse is asked to assess the home environment to determine if it is appropriate for the child to take his medication at home. Which of the following will have the greatest impact on the nurse’s assessment?

A) The mother and grandmother’s understanding about the drugs

B) How clean the house is

C) The health status of the other children

D) Where the medications will be stored

Question 34 A nurse is having difficulty administering a bitter drug to a 5-year-old child. The nurse should

A) have the parent gently force the child’s mouth open.

B) give the drug in a pill form.

C) involve the child in a play therapy session, and then tell the child that the medicine is candy.

D) offer the child a flavored ice chip or ice pop prior to administering the drug.

Question 35 A 22-year-old woman has given birth to an infant who exhibits the signs and symptoms of maternal cocaine use during pregnancy.These signs and symptoms are a result of what pathophysiological effect of opioid use during pregnancy?

A) Changes in blood chemistry as a result of nephrotoxicity and hepatotoxicity

B) Impaired maternal nutrition as a result of drug use

C) Vasoconstriction leading to reduced placental blood flow

D) Hypoxia as a result of a prolonged second stage of labor

Question 36 A preterm neonate received caffeine for the treatment of apnea. The nurse should monitor the neonate for which of the following?

A) Bloody stools

B) Bradycardia

C) Constipation

D) Hypoglycemia

Question 37 A 30-year-old man with a BMI of 59 has recently been diagnosed with type 2 diabetes mellitus. In light of the man’s lack of success with weight loss programs in the past, his care provider has prescribed sibutramine (Meridia). What instructions should the nurse consequently provide to this patient?

A) “Take this drug once each day on an empty stomach.”

B) “It’s best to take a dose of sibutramine after each meal.”

C) “This drug will help you to lose weight without having to exercise or change your normal diet.”

D) “Take a dose when you feel like you are tempted to binge on food.”

Question 38 A nurse practitioner orders a single dose of 2 g Metronidazole orally. How many milligrams will the patient receive in one dose?

A) 1000 mg

B) 2000 mg

C) 3000 mg

D) 4000 mg

Question 39 A nurse is explaining to the parents of a 6-year-old child suffering from angina why nitroglycerin patches for chest pain would not be appropriate.

A) A child has an erratic blood flow from an immature peripheral circulation, which increases drug absorption, causing an increase in adverse effects.

B) A child’s gastric pH is decreased, causing less of the drug to be absorbed from the subcutaneous skin, therefore producing more adverse effects.

C) A child has a greater body surface area, creating greater permeability resulting in an increase in absorption of topical agents, which may result in more adverse effects.

D) A child has a smaller body surface area, resulting in an increase in topical absorption, which can cause more adverse effects.

Question 40 An immunocompromised 7-year-old child was recently discharged home with a peripherally-inserted central line (PIC line) for home antibiotic therapy. He has now been brought to the emergency department by his mother and father with signs and symptoms of line sepsis.Upon questioning, the mother states that she has been removing the PIC dressing daily and washing the site with warm water and a cloth. What nursing diagnosis is most appropriate in this situation?

A) Caregiver Role Strain

B) Ineffective Family Therapeutic Regimen Management

C) Delayed Growth and Development

D) Knowledge Deficit

How is blood circulation to the skin involved in thermoregulation?

Make sure all of the topics in the case study have been addressed.
Cite at least three sources—journal articles, textbooks or evidenced-based websites to support the content.
All sources must be within five years.
Do not use .com, Wikipedia, or up-to-date, etc., for your sources.
Case Study 1

Structure and Function of the Musculoskeletal System

Jennifer belongs to a women’s rugby team. At 23 years old, she has been playing for five years and trains daily to keep up her strength and stamina. During one game, she was injured. Unable to walk, she was carried off the field supported by her coach and an athletic therapist. At the hospital, after an examination and MRI of her right knee, she was given her diagnosis. Jennifer suffered what is often termed the “O’Donoghue triad”: a ruptured medial collateral ligament, a ruptured anterior cruciate ligament, and tear of the medial meniscus.

Jennifer’s injury involved the complete tearing of two ligaments. What are the similarities and differences between the anatomy and function of ligaments and tendons?
Jennifer’s rehabilitation will include techniques that will increase her joint proprioception. What is proprioception, and what will occur if this neural function is not restored?
The knee joint exemplifies a diarthrodial joint. What are the anatomy of the synovial membrane and the importance of synovial fluid in such a joint?
Case Study 2

Disorders of Musculoskeletal Function: Trauma, Infection, Neoplasms

Marvin is a healthy, active 36-year-old who belongs to a martial arts club. Once a week he takes lessons in Judo, and on the weekends, he participates in local competitions. At his last competition, Marvin was paired with a skilled participant from another club. His rival threw him to the mats, and as Marvin struggled, came down hard to pin him down. Marvin heard a snap, followed by instant pain in his left forearm. Radiographs at the local hospital confirmed he suffered a transverse fracture of the distal aspect of his left ulna.

What are the typical signs and symptoms of a fracture? Why shortly after the injury does the pain temporarily subside?
How does a hematoma form, and what function does it serve in the process of healing a fracture?
Marvin was told he would be seeing a physiotherapist as his healing progressed. What are the muscular and joint changes that occur during immobilization and the ways Marvin and his physiotherapist can work to address these changes?
Case Study 3

Disorders of Musculoskeletal Function: Developmental and Metabolic Disorders

Mandy is a 16-year-old competitive figure skater who practices several hours a day with her coach at the skating arena. Because of her extremely active lifestyle and restricted diet to maintain her athletic physique, she experiences ongoing amenorrhea. One day during practice, she landed a jump and fell to the ice in pain. Her left foot swelled up almost immediately, making it difficult for her coach to remove the skate. At the hospital, radiographs revealed a fracture of the fifth metatarsal bone and general radiolucency of all the bones in her foot. A follow-up DXA revealed a bone mass of 2.7 standard deviations below mean.

What is the etiology of Mandy’s premature osteoporosis, and how her condition is thought to contribute to a decrease in bone density?
Knowing what you do about bone mineralization, why does a deficiency of estrogen in women lead to osteoporotic change?
Osteoporosis and osteomalacia both involve abnormal bone mineralization. What are the general macroscopic differences of these two conditions?
Case Study 4

Disorders of Musculoskeletal Function: Rheumatic Disorders

Rick is a 27-year-old who works in an accounting firm. He had started to experience lower back pain and stiffness that he thought were a result of the long hours he spent at his desk. More recently, however, he began to have sleep difficulties. He found that he often woke up during the night feeling hot and sometimes sweaty. Furthermore, his back pain disrupted his sleep, particularly when it radiated around his pelvis and into his thighs. When his lack of sleep began to interfere with his work, he went to an osteopath to see what was wrong. She listened to his case history carefully. Upon physical examination, she noted a slight decrease in his lumbar lordosis and a reduced range of movement in his lumbar spine. His blood tests revealed the presence of HLA-B27, an elevated ESR, and absence of RH. His radiograph showed evidence of sacroiliitis.

What is the likely diagnosis Rick received? What are the common clinical presentation and manifestations of the disease?
Why is osteoarthritis of the hips a potential secondary complication of this disease? What are the structural changes that occur in the articular cartilage of an osteoarthritic joint?
What is the effect of advanced ankylosing spondylitis on lung function?
Case Study 5

Structure and Function of the Skin

Yael is an 18-year-old college student who is bothered by excessive perspiration. She knew she sweat a lot under her arms and kept antiperspirant in her schoolbag to use throughout the day. Yael’s problem was not limited to under her arms, however. Her hands and feet also perspired heavily, and it embarrassed her. She did not like holding her boyfriend’s hand if her hands were particularly sweaty, and she had problems grasping her pen while in class because her palm became slippery. Yael suffered from a condition called primary focal hyperhidrosis, a condition involving hyperactive sweat glands in certain areas of the body.

What are the anatomical and functional differences between eccrine and apocrine glands?
What autonomic nervous system controls the function of thermoregulation of the skin? How do goosebumpsgoose bumps contribute to heat conservation?
Describe the location of the blood plexuses in the skin. How is blood circulation to the skin involved in thermoregulation?
Case Study 6

Disorders of Skin Integrity and Function

Leonard works in the agriculture industry and raises beef cattle. At 60 years of age, he has spent most of his life working outdoors harvesting hay and tending to his herds. His wife was the first to notice a change in his skin. One day, after taking off his shirt, she noticed a significant change in the mole he had on his right shoulder. It not only was darker but was moist and appeared to have been bleeding at one point. Surrounding the mole, his skin was red. His wife remembered hearing stories of Leonard working on his father’s farm, spending long hours out in the hot sun even though his father had gone into the barn to work during the hottest part of the day. She insisted him go to the family physician to have it examined.

Leonard’s physician performed a biopsy on the lesion and told Leonard he suspected the growth may be malignant melanoma. What cells are affected in this form of skin cancer? How might his childhood exposures to the sun predispose him to this form of cancer?
How do UVA and UVB rays contribute to the process of oncogenesis in skin cells?
The mole on Leonard’s shoulder was a nevocellular nevus. What are the cellular composition and appearance of this type of mole before it underwent malignant change?
To view the Grading Rubric for this Assignment, please visit the Grading Rubrics section of the Course Home.

Which of the following would be the nurse’s priority assessments?

tize?

A. Risk for Injury related to drug–drug interactions or drug–nutrient interactions

B. Risk for Constipation related to decreased gastrointestinal peristalsis

C. Risk for Ineffective Peripheral Tissue Perfusion related to cardiovascular effects of phenelzine

D. Risk for Infection related to immunosuppressive effects of phenelzine

1 points

Question 21

A nurse works in a sleep disorder clinic and is responsible for administering medications to the patients. Which of the following patients would be most likely to receive zaleplon (Sonata)?

A. A 20-year-old woman who will take the drug about once a week

B. A 46-year-old man who receives an antidepressant and needs a sleep aid

C. A 35-year-old man who is having difficulty falling asleep, but once asleep can stay asleep

D. A 52-year-old woman who needs to fall asleep quickly and stay asleep all night

1 points

Question 22

A 26-year-old professional began using cocaine recreationally several months ago and has begun using the drug on a daily basis over the past few weeks. He has noticed that he now needs to take larger doses of cocaine in order to enjoy the same high that he used to experience when he first used the drug. A nurse should recognize that this pattern exemplifies

A. drug tolerance.

B. dependence.

C. addiction.

D. withdrawal.

1 points

Question 23

A postsurgical patient has been provided with a morphine patient-controlled analgesic (PCA) but has expressed her reluctance to use it for fear of becoming addicted. How can the nurse best respond to this patient’s concerns?

A. “It is not uncommon to develop a dependence on pain medications, but this usually takes place over a long period and is not the same as addiction.”

B. “You don’t need to worry. It’s actually not true that you can get addicted to the medications we use in a hospital setting.”

C. “It’s important that you accept that your current need to control your pain is more important than fears of becoming addicted.”

D. “If you do become addicted, we’ll make sure to provide you with the support and resources necessary to help you with your recovery.”

1 points

Question 24

A patient has been prescribed zolpidem (Ambien) for short-term treatment of insomnia. Which of the following will the nurse include in a teaching plan for this patient? (Select all that apply.)

A. The drug does not cause sleepiness in the morning.

B. It is available in both quick-onset and continuous-release oral forms.

C. The drug should not be used for longer than 1 month.

D. It should be taken 1 hour to 90 minutes before going to bed.

E. One of the most common adverse effects of the drug is headache.

1 points

Question 25

A patient who is experiencing withdrawal from heavy alcohol use have developed psychosis and been treated with haloperidol. Which of the following assessment findings should prompt the care team to assess the patient for neuroleptic malignant syndrome?

A. The patient develops yellowed sclerae and intense pruritis (itchiness).

B. The patient demonstrates a significant increase in agitation after being given haloperidol.

C. The patient develops muscle rigidity and a sudden, high fever.

D. The patient complains of intense thirst and produces copious amounts of urine.

1 points

Question 26

A nurse is providing care for a patient who suffered extensive burns to his extremities during a recent industrial accident. Topical lidocaine gel has been ordered to be applied to the surfaces of all his burns in order to achieve adequate pain control. When considering this order, the nurse should be aware that

A. there is a risk of systemic absorption of the lidocaine through the patient’s traumatized skin.

B. intravenous lidocaine may be preferable to topical application.

C. lidocaine must be potentiated with another anesthetic in order to achieve pain control.

D. pain relief is unlikely to be achieved due to the destruction of nerve endings in the burn site.

1 points

Question 27

Which of the following drugs used to treat anxiety would be appropriate for a patient who is a school teacher and is concerned about feeling sedated at work?

A. Lorazepam (Ativan)

B. Diazepam (Valium)

C. Alprazolam (Xanax)

D. Buspirone (BuSpar)

1 points

Question 28

A nurse is caring for a patient who is in severe pain and is receiving an opioid analgesic. Which of the following would be the nurse’s priority assessments?

A. Liver function studies, pain intensity, and blood glucose level

B. Pain intensity, respiratory rate, and level of consciousness

C. Respiratory rate, seizure activity, and electrolytes

D. Respiratory rate, pain intensity, and mental status

1 points

Question 29

A male patient has been brought to the emergency department during an episode of status epilepticus. Diazepam is to be administered intravenously. The nurse will be sure to

A. administer after diluting the drug with gabapentin in intravenous solution.

B. inject very slowly, no faster than 100 mg/minute.

C. inject the diazepam very quickly, 15 mg in 10 to15 seconds.

D. avoid the small veins in the dorsum of the hand or the wrist.

1 points

Question 30

A 30-year-old woman is taking phenelzine (Nardil) 30mg PO tid. The nurse knows that at that dosage, the patient will need to be carefully monitored for

A. increased secretions.

B. facial flushing.

C. dizziness

Why do you think the smaller t values are not statistically significant?

Study Questions
1. Are independent or dependent (paired) scores examined in this study? Provide a rationale for your answer.

2. What independent (intervention) and dependent (outcome) variables were included in this study?

3. What inferential statistical technique was calculated to examine differences in the participants when they received the high-aspartame diet intervention versus the low-aspartame diet? Is this technique appropriate? Provide a rationale for your answer.

4. What statistical techniques were calculated to describe spatial orientation for the participants consuming low- and high-aspartame diets? Were these techniques appropriate? Provide a rationale for your answer.

5. What was the dispersion of the scores for spatial orientation for the high- and low-aspartame diets? Is the dispersion of these scores similar or different? Provide a rationale for your answer.

6. What is the paired t-test value for spatial orientation between the participants’ consumption of high- and low-aspartame diets? Are these results significant? Provide a rationale for your answer.

174
7. State the null hypothesis for spatial orientation for this study. Was this hypothesis accepted or rejected? Provide a rationale for your answer.

8. Discuss the meaning of the results regarding spatial orientation for this study. What is the clinical importance of this result? Document your answer.

9. Was there a significant difference in the participants’ reported headaches between the high- and low-aspartame intake periods? What does the result indicate?

10. What additional research is needed to determine the neurobehavioral effects of aspartame consumption?

175
Answers to Study Questions
1. This study was conducted using one group of 28 college students who consumed both high- and low- aspartame diets and differences in their responses to these two diets (interventions) were examined. Lindseth et al. (2014, p. 187) stated that “the participants served as their own controls” in this study, indicating the scores from the one group are paired. In Table 2, the t-tests are identified as paired t-tests, which are conducted on dependent or paired samples.

2. The interventions were high-aspartame diet (25 mg/kg body weight/day) and low-aspartame diet (10 mg/kg body weight/day). The dependent or outcome variables were spatial orientation, working memory, mood (irritability), depression, and headaches (see Table 2 and narrative of results).

3. Differences were examined with the paired t-test (see Table 2). This statistical technique is appropriate since the study included one group and the participants served as their own control (Plichta & Kelvin, 2013). The dependent variables were measured at least at the interval level for each subject following their consumption of high- and low-aspartame diets and were then examined for differences to determine the effects of the two aspartame diets.

4. Means and standard deviations (SDs) were used to describe spatial orientation for high- and low-aspartame diets. The data in the study were considered at least interval level, so means and SDs are the appropriate analysis techniques for describing the study dependent variables (Grove et al., 2013).

5. Standard deviation (SD) is a measure of dispersion that was reported in this study. Spatial orientation following a high-aspartame diet had an SD = 4.2 and an SD = 4.3 for a low-aspartame diet. These SDs are very similar, indicating similar dispersions of spatial orientation scores following the two aspartame diets.

6. Paired t-test = 2.4 for spatial orientation, which is a statistically significant result since p = .03*. The single asterisk (*) directs the reader to the footnote at the bottom of the table, which identifies * p < .05. Since the study result of p = .03 is less than α = .05 set for this study, then the result is statistically significant.

7. There is no significant difference in spatial orientation scores for participants following consumption of a low-aspartame diet versus a high-aspartame diet. The null hypothesis was rejected because of the significant difference found for spatial orientation (see the answer to Question 6). Significant results cause the rejection of the null hypothesis and lend support to the research hypothesis that the levels of aspartame do effect spatial orientation.

8. The researchers reported, “Based on Vandenberg MRT scores, spatial orientation scores were significantly better for participants after their low-aspartame intake period than after their high intake period (Table 2)” (Lindseth et al., 2014, p. 190). This result is clinically important since the high-aspartame diet significantly reduced the participants' spatial orientation. 176Healthcare providers need to be aware of this finding, since it is consistent with previous research, and encourage people to consume fewer diet drinks and foods with aspartame. The American Heart Association and the American Diabetic Association have provided a statement about the effects of aspartame that can be found on the National Guideline Clearinghouse website at http://www.guideline.gov/content.aspx?id=38431&search=effects+aspartame.

9. There was no significant difference in reported headaches based on the level (high or low) of aspartame diet consumed. Additional research is needed to determine if this result is an accurate reflection of reality or is due to design weaknesses, sampling or data collection errors, or chance (Grove et al., 2013).

10. Additional studies are needed with larger samples to determine the effects of aspartame in the diet. Lindseth et al. (2014) conducted a power analysis that indicated the sample size should have been at least 30 participants. Thus, the sample size was small at N = 28, which increased the potential for a Type II error. Diets higher in aspartame (40–50 mg/kg body weight/day) should be examined for neurobehavioral effects. Longitudinal studies to examine the effects of aspartame over more than 8 days are needed. Future research needs to examine the length of washout period needed between the different levels of aspartame diets. Researchers also need to examine the measurement methods to ensure they have strong validity and reliability. Could a stronger test of working memory be used in future research?

177
EXERCISE 17 Questions to Be Graded
Name: _______________________________________________________ Class: _____________________

Date: ___________________________________________________________________________________

Follow your instructor's directions to submit your answers to the following questions for grading. Your instructor may ask you to write your answers below and submit them as a hard copy for grading. Alternatively, your instructor may ask you to use the space below for notes and submit your answers online at http://evolve.elsevier.com/Grove/Statistics/ under “Questions to Be Graded.”

1. What are the assumptions for conducting a paired or dependent samples t-test in a study? Which of these assumptions do you think were met by the Lindseth et al. (2014) study?

2. In the introduction, Lindseth et al. (2014) described a “2-week washout between diets.” What does this mean? Why is this important?

3. What is the paired t-test value for mood (irritability) between the participants' consumption of high- versus low-aspartame diets? Is this result statistically significant? Provide a rationale for your answer.

4. State the null hypothesis for mood (irritability) that was tested in this study. Was this hypothesis accepted or rejected? Provide a rationale for your answer.

178
5. Which t value in Table 2 represents the greatest relative or standardized difference between the high- and low-aspartame diets? Is this t value statistically significant? Provide a rationale for your answer.

6. Discuss why the larger t values are more likely to be statistically significant.

7. Discuss the meaning of the results regarding depression for this study. What is the clinical importance of this result?

8. What is the smallest, paired t-test value in Table 2? Why do you think the smaller t values are not statistically significant?

9. Discuss the clinical importance of these study results about the consumption of aspartame. Document your answer with a relevant source.

10. Are these study findings related to the consumption of high- and low-aspartame diets ready for implementation in practice? Provide a rationale for your answer.

|
Exercise 17
Understanding Paired or Dependent Samples t-Test
Statistical Technique in Review
The paired or dependent samples t-test is a parametric statistical procedure calculated to determine differences between two sets of repeated measures data from one group of people. The scores used in the analysis might be obtained from the same subjects under different conditions, such as the one group pretest–posttest design. With this type of design, a single group of subjects experiences the pretest, treatment, and posttest. Subjects are referred to as serving as their own control during the pretest, which is then compared with the posttest scores following the treatment. Paired scores also result from a one-group repeated measures design, where one group of participants is exposed to different levels of an intervention. For example, one group of participants might be exposed to two different doses of a medication and the outcomes for each participant for each dose of medication are measured, resulting in paired scores. The one group design is considered a weak quasi-experimental design because it is difficult to determine the effects of a treatment without a comparison to a separate control group (Shadish, Cook, & Campbell, 2002).

A less common type of paired groups is when the groups are matched as part of the design to ensure similarities between the two groups and thus reduce the effect of extraneous variables (Grove, Burns, & Gray, 2013; Shadish et al., 2002). For example, two groups might be matched on demographic variables such as gender, age, and severity of illness to reduce the extraneous effects of these variables on the study results. The assumptions for the paired samples t-test are as follows:

1. The distribution of scores is normal or approximately normal.

2. The dependent variable(s) is(are) measured at interval or ratio levels.

3. Repeated measures data are collected from one group of subjects, resulting in paired scores.

4. The differences between the paired scores are independent.

Research Article
Source
Lindseth, G. N., Coolahan, S. E., Petros, T. V., & Lindseth, P. D. (2014). Neurobehavioral effects of aspartame consumption. Research in Nursing & Health, 37(3), 185–193.

Introduction
Despite the widespread use of the artificial sweetener aspartame in drinks and food, there are concern and controversy about the mixed research evidence on its neurobehavioral 172effects. Thus Lindseth and colleagues (2014) conducted a one-group repeated measures design to determine the neurobehavioral effects of consuming both low- and high-aspartame diets in a sample of 28 college students. “The participants served as their own controls. . . . A random assignment of the diets was used to avoid an error of variance for possible systematic effects of order” (Lindseth et al., 2014, p. 187). “Healthy adults who consumed a study-prepared high-aspartame diet (25 mg/kg body weight/day) for 8 days and a low-aspartame diet (10 mg/kg body weight/day) for 8 days, with a 2-week washout between the diets, were examined for within-subject differences in cognition, depression, mood, and headache. Measures included weight of foods consumed containing aspartame, mood and depression scales, and cognitive tests for working memory and spatial orientation. When consuming high-aspartame diets, participants had more irritable mood, exhibited more depression, and performed worse on spatial orientation tests. Aspartame consumption did not influence working memory. Given that the higher intake level tested here was well below the maximum acceptable daily intake level of 40–50 mg/kg body weight/day, careful consideration is warranted when consuming food products that may affect neurobehavioral health” (Lindseth et al., 2014, p. 185).

Relevant Study Results
“The mean age of the study participants was 20.8 years (SD = 2.5). The average number of years of education was 13.4 (SD = 1.0), and the mean body mass index was 24.1 (SD = 3.5). . . . Based on Vandenberg MRT scores, spatial orientation scores were significantly better for participants after their low-aspartame intake period than after their high intake period (Table 2). Two participants had clinically significant cognitive impairment after consuming high-aspartame diets. . . . Participants were significantly more depressed after they consumed the high-aspartame diet compared to when they consumed the low-aspartame diet (Table 2). . . . Only one participant reported a headache; no difference in headache incidence between high- and low-aspartame intake periods could be established” (Lindseth et al., 2014, p. 190).

TABLE 2

WITHIN-SUBJECT DIFFERENCES IN NEUROBEHAVIOR SCORES AFTER HIGH AND LOW ASPARTAME INTAKE (N = 28)

Variable M SD Paired t-Test p
Spatial orientation
High-aspartame 14.1 4.2 2.4 .03*
Low-aspartame 16.6 4.3
Working memory
High-aspartame 730.0 152.7 1.5 N.S.
Low-aspartame 761.1 201.6
Mood (irritability)
High-aspartame 33.4 9.0 3.4 .002**
Low-aspartame 30.5 7.3
Depression
High-aspartame 36.8 7.0 3.8 .001**
Low-aspartame 34.4 6.2
image

*p < .05.

**p < .01.

M = Mean; SD = Standard deviation; N.S. = Nonsignificant.

Lindseth, G. N., Coolahan, S. E., Petros, T. V., & Lindseth, P. D. (2014). Neurobehavioral effects of aspartame consumption. Research in Nursing & Health, 37(3), p. 190

173
Study Questions
1. Are independent or dependent (paired) scores examined in this study? Provide a rationale for your answer.

2. What independent (intervention) and dependent (outcome) variables were included in this study?

3. What inferential statistical technique was calculated to examine differences in the participants when they received the high-aspartame diet intervention versus the low-aspartame diet? Is this technique appropriate? Provide a rationale for your answer.

4. What statistical techniques were calculated to describe spatial orientation for the participants consuming low- and high-aspartame diets? Were these techniques appropriate? Provide a rationale for your answer.

5. What was the dispersion of the scores for spatial orientation for the high- and low-aspartame diets? Is the dispersion of these scores similar or different? Provide a rationale for your answer.

6. What is the paired t-test value for spatial orientation between the participants' consumption of high- and low-aspartame diets? Are these results significant? Provide a rationale for your answer.

174
7. State the null hypothesis for spatial orientation for this study. Was this hypothesis accepted or rejected? Provide a rationale for your answer.

8. Discuss the meaning of the results regarding spatial orientation for this study. What is the clinical importance of this result? Document your answer.

9. Was there a significant difference in the participants' reported headaches between the high- and low-aspartame intake periods? What does the result indicate?

10. What additional research is needed to determine the neurobehavioral effects of aspartame consumption?

175
Answers to Study Questions
1. This study was conducted using one group of 28 college students who consumed both high- and low- aspartame diets and differences in their responses to these two diets (interventions) were examined. Lindseth et al. (2014, p. 187) stated that “the participants served as their own controls” in this study, indicating the scores from the one group are paired. In Table 2, the t-tests are identified as paired t-tests, which are conducted on dependent or paired samples.

2. The interventions were high-aspartame diet (25 mg/kg body weight/day) and low-aspartame diet (10 mg/kg body weight/day). The dependent or outcome variables were spatial orientation, working memory, mood (irritability), depression, and headaches (see Table 2 and narrative of results).

3. Differences were examined with the paired t-test (see Table 2). This statistical technique is appropriate since the study included one group and the participants served as their own control (Plichta & Kelvin, 2013). The dependent variables were measured at least at the interval level for each subject following their consumption of high- and low-aspartame diets and were then examined for differences to determine the effects of the two aspartame diets.

4. Means and standard deviations (SDs) were used to describe spatial orientation for high- and low-aspartame diets. The data in the study were considered at least interval level, so means and SDs are the appropriate analysis techniques for describing the study dependent variables (Grove et al., 2013).

5. Standard deviation (SD) is a measure of dispersion that was reported in this study. Spatial orientation following a high-aspartame diet had an SD = 4.2 and an SD = 4.3 for a low-aspartame diet. These SDs are very similar, indicating similar dispersions of spatial orientation scores following the two aspartame diets.

6. Paired t-test = 2.4 for spatial orientation, which is a statistically significant result since p = .03*. The single asterisk (*) directs the reader to the footnote at the bottom of the table, which identifies * p < .05. Since the study result of p = .03 is less than α = .05 set for this study, then the result is statistically significant.

7. There is no significant difference in spatial orientation scores for participants following consumption of a low-aspartame diet versus a high-aspartame diet. The null hypothesis was rejected because of the significant difference found for spatial orientation (see the answer to Question 6). Significant results cause the rejection of the null hypothesis and lend support to the research hypothesis that the levels of aspartame do effect spatial orientation.

8. The researchers reported, “Based on Vandenberg MRT scores, spatial orientation scores were significantly better for participants after their low-aspartame intake period than after their high intake period (Table 2)” (Lindseth et al., 2014, p. 190). This result is clinically important since the high-aspartame diet significantly reduced the participants' spatial orientation. 176Healthcare providers need to be aware of this finding, since it is consistent with previous research, and encourage people to consume fewer diet drinks and foods with aspartame. The American Heart Association and the American Diabetic Association have provided a statement about the effects of aspartame that can be found on the National Guideline Clearinghouse website at http://www.guideline.gov/content.aspx?id=38431&search=effects+aspartame.

9. There was no significant difference in reported headaches based on the level (high or low) of aspartame diet consumed. Additional research is needed to determine if this result is an accurate reflection of reality or is due to design weaknesses, sampling or data collection errors, or chance (Grove et al., 2013).

10. Additional studies are needed with larger samples to determine the effects of aspartame in the diet. Lindseth et al. (2014) conducted a power analysis that indicated the sample size should have been at least 30 participants. Thus, the sample size was small at N = 28, which increased the potential for a Type II error. Diets higher in aspartame (40–50 mg/kg body weight/day) should be examined for neurobehavioral effects. Longitudinal studies to examine the effects of aspartame over more than 8 days are needed. Future research needs to examine the length of washout period needed between the different levels of aspartame diets. Researchers also need to examine the measurement methods to ensure they have strong validity and reliability. Could a stronger test of working memory be used in future research?

177
EXERCISE 17 Questions to Be Graded
Name: _______________________________________________________ Class: _____________________

Date: ___________________________________________________________________________________

Follow your instructor's directions to submit your answers to the following questions for grading. Your instructor may ask you to write your answers below and submit them as a hard copy for grading. Alternatively, your instructor may ask you to use the space below for notes and submit your answers online at http://evolve.elsevier.com/Grove/Statistics/ under “Questions to Be Graded.”

1. What are the assumptions for conducting a paired or dependent samples t-test in a study? Which of these assumptions do you think were met by the Lindseth et al. (2014) study?

2. In the introduction, Lindseth et al. (2014) described a “2-week washout between diets.” What does this mean? Why is this important?

3. What is the paired t-test value for mood (irritability) between the participants' consumption of high- versus low-aspartame diets? Is this result statistically significant? Provide a rationale for your answer.

4. State the null hypothesis for mood (irritability) that was tested in this study. Was this hypothesis accepted or rejected? Provide a rationale for your answer.

178
5. Which t value in Table 2 represents the greatest relative or standardized difference between the high- and low-aspartame diets? Is this t value statistically significant? Provide a rationale for your answer.

6. Discuss why the larger t values are more likely to be statistically significant.

7. Discuss the meaning of the results regarding depression for this study. What is the clinical importance of this result?

8. What is the smallest, paired t-test value in Table 2? Why do you think the smaller t values are not statistically significant?

9. Discuss the clinical importance of these study results about the consumption of aspartame. Document your answer with a relevant source.

10. Are these study findings related to the consumption of high- and low-aspartame diets ready for implementation in practice? Provide a rationale for your answer.

There are two exercises that i posted exercise 16 and 17. both exercises has 10 questions at the end which says questions to be graded. I need to do that questions.

What variable has a result of t = −6.135, p = 0.000? What does the result mean?

Understanding Independent Samples t-Test
Statistical Technique in Review
The independent samples t-test is a parametric statistical technique used to determine significant differences between the scores obtained from two samples or groups. Since the t-test is considered fairly easy to calculate, researchers often use it in determining differences between two groups. The t-test examines the differences between the means of the two groups in a study and adjusts that difference for the variability (computed by the standard error) among the data. When interpreting the results of t-tests, the larger the calculated t ratio, in absolute value, the greater the difference between the two groups. The significance of a t ratio can be determined by comparison with the critical values in a statistical table for the t distribution using the degrees of freedom (df) for the study (see Appendix A Critical Values for Student’s t Distribution at the back of this text). The formula for df for an independent t-test is as follows:

df=(numberofsubjectsinsample1+numberofsubjectsinsample2)−2

image
Exampledf=(65insample1+67insample2)−2=132−2=130

image
The t-test should be conducted only once to examine differences between two groups in a study, because conducting multiple t-tests on study data can result in an inflated Type 1 error rate. A Type I error occurs when the researcher rejects the null hypothesis when it is in actuality true. Researchers need to consider other statistical analysis options for their study data rather than conducting multiple t-tests. However, if multiple t-tests are conducted, researchers can perform a Bonferroni procedure or more conservative post hoc tests like Tukey’s honestly significant difference (HSD), Student-Newman-Keuls, or Scheffé test to reduce the risk of a Type I error. Only the Bonferroni procedure is covered in this text; details about the other, more stringent post hoc tests can be found in Plichta and Kelvin (2013) and Zar (2010).

The Bonferroni procedure is a simple calculation in which the alpha is divided by the number of t-tests conducted on different aspects of the study data. The resulting number is used as the alpha or level of significance for each of the t-tests conducted. The Bonferroni procedure formula is as follows: alpha (α) ÷ number of t-tests performed on study data = more stringent study α to determine the significance of study results. For example, if a study’s α was set at 0.05 and the researcher planned on conducting five t-tests on the study data, the α would be divided by the five t-tests (0.05 ÷ 5 = 0.01), with a resulting α of 0.01 to be used to determine significant differences in the study.

The t-test for independent samples or groups includes the following assumptions:

1. The raw scores in the population are normally distributed.

2. The dependent variable(s) is(are) measured at the interval or ratio levels.

162
3. The two groups examined for differences have equal variance, which is best achieved by a random sample and random assignment to groups.

4. All scores or observations collected within each group are independent or not related to other study scores or observations.

The t-test is robust, meaning the results are reliable even if one of the assumptions has been violated. However, the t-test is not robust regarding between-samples or within-samples independence assumptions or with respect to extreme violation of the assumption of normality. Groups do not need to be of equal sizes but rather of equal variance. Groups are independent if the two sets of data were not taken from the same subjects and if the scores are not related (Grove, Burns, & Gray, 2013; Plichta & Kelvin, 2013). This exercise focuses on interpreting and critically appraising the t-tests results presented in research reports. Exercise 31 provides a step-by-step process for calculating the independent samples t-test.

Research Article
Source
Canbulat, N., Ayhan, F., & Inal, S. (2015). Effectiveness of external cold and vibration for procedural pain relief during peripheral intravenous cannulation in pediatric patients. Pain Management Nursing, 16(1), 33–39.

Introduction
Canbulat and colleagues (2015, p. 33) conducted an experimental study to determine the “effects of external cold and vibration stimulation via Buzzy on the pain and anxiety levels of children during peripheral intravenous (IV) cannulation.” Buzzy is an 8 × 5 × 2.5 cm battery-operated device for delivering external cold and vibration, which resembles a bee in shape and coloring and has a smiling face. A total of 176 children between the ages of 7 and 12 years who had never had an IV insertion before were recruited and randomly assigned into the equally sized intervention and control groups. During IV insertion, “the control group received no treatment. The intervention group received external cold and vibration stimulation via Buzzy . . . Buzzy was administered about 5 cm above the application area just before the procedure, and the vibration continued until the end of the procedure” (Canbulat et al., 2015, p. 36). Canbulat et al. (2015, pp. 37–38) concluded that “the application of external cold and vibration stimulation were effective in relieving pain and anxiety in children during peripheral IV” insertion and were “quick-acting and effective nonpharmacological measures for pain reduction.” The researchers concluded that the Buzzy intervention is inexpensive and can be easily implemented in clinical practice with a pediatric population.

Relevant Study Results
The level of significance for this study was set at α = 0.05. “There were no differences between the two groups in terms of age, sex [gender], BMI, and preprocedural anxiety according to the self, the parents’, and the observer’s reports (p > 0.05) (Table 1). When the pain and anxiety levels were compared with an independent samples t test, . . . the children in the external cold and vibration stimulation [intervention] group had significantly lower pain levels than the control group according to their self-reports (both WBFC [Wong Baker Faces Scale] and VAS [visual analog scale] scores; p < 0.001) (Table 2). The external cold and vibration stimulation group had significantly lower fear and anxiety 163levels than the control group, according to parents' and the observer's reports (p < 0.001) (Table 3)” (Canbulat et al., 2015, p. 36).

TABLE 1

COMPARISON OF GROUPS IN TERMS OF VARIABLES THAT MAY AFFECT PROCEDURAL PAIN AND ANXIETY LEVELS

Characteristic Buzzy (n = 88) Control (n = 88) χ2
p
Sex
Female (%), n 11 (12.5) 13 (14.8) .82
Male (%), n 77 (87.5) 75 (85.2) .41
Characteristic Buzzy (n = 88) Control (n = 88) t
p
Age (mean ± SD) 8.25 ± 1.51 8.61 ± 1.69 −1.498
.136
BMI (mean ± SD) 25.41 ± 6.74 26.94 ± 8.68 −1.309
.192
Preprocedural anxiety
Self-report (mean ± SD) 2.03 ± 1.29 2.11 ± 1.58 −0.364
.716
Parent report (mean ± SD) 2.11 ± 1.20 2.17 ± 1.42 −0.285
.776
Observer report (mean ± SD) 2.18 ± 1.17 2.24 ± 1.37 −0.295
.768
image

BMI, body mass index.

Canbulat, N., Ayban, F., & Inal, S. (2015). Effectiveness of external cold and vibration for procedural pain relief during peripheral intravenous cannulation in pediatric patients. Pain Management Nursing, 16(1), p. 36.

TABLE 2

COMPARISON OF GROUPS' PROCEDURAL PAIN LEVELS DURING PERIPHERAL IV CANNULATION

Buzzy (n = 88) Control (n = 88) t
p
Procedural self-reported pain with WBFS (mean ± SD) 2.75 ± 2.68 5.70 ± 3.31 −6.498
0.000
Procedural self-reported pain with VAS (mean ± SD) 1.66 ± 1.95 4.09 ± 3.21 −6.065
0.000
image

IV, intravenous; WBFS, Wong-Baker Faces Scale; SD, standard deviation; VAS, visual analog scale.

Canbulat, N., Ayban, F., & Inal, S. (2015). Effectiveness of external cold and vibration for procedural pain relief during peripheral intravenous cannulation in pediatric patients. Pain Management Nursing, 16(1), p. 37.

TABLE 3

COMPARISON OF GROUPS' PROCEDURAL ANXIETY LEVELS DURING PERIPHERAL IV CANNULATION

Procedural Child Anxiety Buzzy (n = 88) Control (n = 88) t
p
Parent reported (mean ± SD) 0.94 ± 1.06 2.09 ± 1.39 −6.135
0.000
Observer reported (mean ± SD) 0.92 ± 1.03 2.14 ± 1.34 −6.745
0.000
image

SD, standard deviation; IV, intravenous.

Canbulat, N., Ayban, F., & Inal, S. (2015). Effectiveness of external cold and vibration for procedural pain relief during peripheral intravenous cannulation in pediatric patients. Pain Management Nursing, 16(1), p. 37.

164
Study Questions
1. What type of statistical test was conducted by Canbulat et al. (2015) to examine group differences in the dependent variables of procedural pain and anxiety levels in this study? What two groups were analyzed for differences?

2. What did Canbulat et al. (2015) set the level of significance, or alpha (α), at for this study?

3. What are the t and p (probability) values for procedural self-reported pain measured with a visual analog scale (VAS)? What do these results mean?

4. What is the null hypothesis for observer-reported procedural anxiety for the two groups? Was this null hypothesis accepted or rejected in this study? Provide a rationale for your answer.

5. What is the t-test result for BMI? Is this result statistically significant? Provide a rationale for your answer. What does this result mean for the study?

165
6. What causes an increased risk for Type I errors when t-tests are conducted in a study? How might researchers reduce the increased risk for a Type I error in a study?

7. Assuming that the t-tests presented in Table 2 and Table 3 are all the t-tests performed by Canbulat et al. (2015) to analyze the dependent variables' data, calculate a Bonferroni procedure for this study.

8. Would the t-test for observer-reported procedural anxiety be significant based on the more stringent α calculated using the Bonferroni procedure in question 7? Provide a rationale for your answer.

9. The results in Table 1 indicate that the Buzzy intervention group and the control group were not significantly different for gender, age, body mass index (BMI), or preprocedural anxiety (as measured by self-report, parent report, or observer report). What do these results indicate about the equivalence of the intervention and control groups at the beginning of the study? Why are these results important?

10. Canbulat et al. (2015) conducted the χ2 test to analyze the difference in sex or gender between the Buzzy intervention group and the control group. Would an independent samples t-test be appropriate to analyze the gender data in this study (review algorithm in Exercise 12)? Provide a rationale for your answer.

166
Answers to Study Questions
1. An independent samples t-test was conducted to examine group differences in the dependent variables in this study. The two groups analyzed for differences were the Buzzy experimental or intervention group and the control group.

2. The level of significance or alpha (α) was set at 0.05.

3. The result was t = −6.065, p = 0.000 for procedural self-reported pain with the VAS (see Table 2). The t value is statistically significant as indicated by the p = 0.000, which is less than α = 0.05 set for this study. The t result means there is a significant difference between the Buzzy intervention group and the control group in terms of the procedural self-reported pain measured with the VAS. As a point of clarification, p values are never zero in a study. There is always some chance of error.

4. The null hypothesis is: There is no difference in observer-reported procedural anxiety levels between the Buzzy intervention and the control groups for school-age children. The t = −6.745 for observer-reported procedural anxiety levels, p = 0.000, which is less than α = 0.05 set for this study. Since this study result was statistically significant, the null hypothesis was rejected.

5. The t = −1.309 for BMI. The nonsignificant p = .192 for BMI is greater than α = 0.05 set for this study. The nonsignificant result means there is no statistically significant difference between the Buzzy intervention and control groups for BMI. The two groups need to be similar for demographic variables to decrease the potential for error and increase the likelihood that the results are an accurate reflection of reality.

6. The conduct of multiple t-tests causes an increased risk for Type I errors. If only one t-test is conducted on study data, the risk of Type I error does not increase. The Bonferroni procedure and the more stringent Tukey's honestly significant difference (HSD), Student Newman-Keuls, or Scheffé test can be calculated to reduce the risk of a Type I error (Plichta & Kelvin, 2013; Zar, 2010).

7. The Bonferroni procedure is calculated by alpha ÷ number of t-tests conducted on study variables' data. Note that researchers do not always report all t-tests conducted, especially if they were not statistically significant. The t-tests conducted on demographic data are not of concern. Canbulat et al. reported the results of four t-tests conducted to examine differences between the intervention and control groups for the dependent variables procedural self-reported pain with WBFS, procedural self-reported pain with VAS, parent-reported anxiety levels, and observer-reported anxiety levels. The Bonferroni calculation for this study: 0.05 (alpha) ÷ number of t-tests conducted = 0.05 ÷ 4 = 0.0125. The new α set for the study is 0.0125.

8. Based on the Bonferroni result = 0.0125 obtained in Question 7, the t = −6.745, p = 0.000, is still significant since it is less than 0.0125.

167
9. The intervention and control groups were examined for differences related to the demographic variables gender, age, and BMI and the dependent variable preprocedural anxiety that might have affected the procedural pain and anxiety posttest levels in the children 7 to 12 years old. These nonsignificant results indicate the intervention and control groups were similar or equivalent for these variables at the beginning of the study. Thus, Canbulat et al. (2015) can conclude the significant differences found between the two groups for procedural pain and anxiety levels were probably due to the effects of the intervention rather than sampling error or initial group differences.

10. No, the independent samples t-test would not have been appropriate to analyze the differences in gender between the Buzzy intervention and control groups. The demographic variable gender is measured at the nominal level or categories of females and males. Thus, the χ2 test is the appropriate statistic for analyzing gender data (see Exercise 19). In contrast, the t-test is appropriate for analyzing data for the demographic variables age and BMI measured at the ratio level.

169
EXERCISE 16 Questions to Be Graded
Follow your instructor's directions to submit your answers to the following questions for grading. Your instructor may ask you to write your answers below and submit them as a hard copy for grading. Alternatively, your instructor may ask you to use the space below for notes and submit your answers online at http://evolve.elsevier.com/Grove/Statistics/ under “Questions to Be Graded.”

Name: _______________________________________________________ Class: _____________________

Date: ___________________________________________________________________________________

1. What do degrees of freedom (df) mean? Canbulat et al. (2015) did not provide the dfs in their study. Why is it important to know the df for a t ratio? Using the df formula, calculate the df for this study.

2. What are the means and standard deviations (SDs) for age for the Buzzy intervention and control groups? What statistical analysis is conducted to determine the difference in means for age for the two groups? Was this an appropriate analysis technique? Provide a rationale for your answer.

3. What are the t value and p value for age? What do these results mean?

4. What are the assumptions for conducting the independent samples t-test?

170
5. Are the groups in this study independent or dependent? Provide a rationale for your answer.

6. What is the null hypothesis for procedural self-reported pain measured with the Wong Baker Faces Scale (WBFS) for the two groups? Was this null hypothesis accepted or rejected in this study? Provide a rationale for your answer.

7. Should a Bonferroni procedure be conducted in this study? Provide a rationale for your answer.

8. What variable has a result of t = −6.135, p = 0.000? What does the result mean?

9. In your opinion, is it an expected or unexpected finding that both t values on Table 2 were found to be statistically significant. Provide a rationale for your answer.

10. Describe one potential clinical benefit for pediatric patients to receive the Buzzy intervention that combined cold and vibration

Exercise 17
Understanding Paired or Dependent Samples t-Test
Statistical Technique in Review
The paired or dependent samples t-test is a parametric statistical procedure calculated to determine differences between two sets of repeated measures data from one group of people. The scores used in the analysis might be obtained from the same subjects under different conditions, such as the one group pretest–posttest design. With this type of design, a single group of subjects experiences the pretest, treatment, and posttest. Subjects are referred to as serving as their own control during the pretest, which is then compared with the posttest scores following the treatment. Paired scores also result from a one-group repeated measures design, where one group of participants is exposed to different levels of an intervention. For example, one group of participants might be exposed to two different doses of a medication and the outcomes for each participant for each dose of medication are measured, resulting in paired scores. The one group design is considered a weak quasi-experimental design because it is difficult to determine the effects of a treatment without a comparison to a separate control group (Shadish, Cook, & Campbell, 2002).

A less common type of paired groups is when the groups are matched as part of the design to ensure similarities between the two groups and thus reduce the effect of extraneous variables (Grove, Burns, & Gray, 2013; Shadish et al., 2002). For example, two groups might be matched on demographic variables such as gender, age, and severity of illness to reduce the extraneous effects of these variables on the study results. The assumptions for the paired samples t-test are as follows:

1. The distribution of scores is normal or approximately normal.

2. The dependent variable(s) is(are) measured at interval or ratio levels.

3. Repeated measures data are collected from one group of subjects, resulting in paired scores.

4. The differences between the paired scores are independent.

Research Article
Source
Lindseth, G. N., Coolahan, S. E., Petros, T. V., & Lindseth, P. D. (2014). Neurobehavioral effects of aspartame consumption. Research in Nursing & Health, 37(3), 185–193.

Introduction
Despite the widespread use of the artificial sweetener aspartame in drinks and food, there are concern and controversy about the mixed research evidence on its neurobehavioral 172effects. Thus Lindseth and colleagues (2014) conducted a one-group repeated measures design to determine the neurobehavioral effects of consuming both low- and high-aspartame diets in a sample of 28 college students. “The participants served as their own controls. . . . A random assignment of the diets was used to avoid an error of variance for possible systematic effects of order” (Lindseth et al., 2014, p. 187). “Healthy adults who consumed a study-prepared high-aspartame diet (25 mg/kg body weight/day) for 8 days and a low-aspartame diet (10 mg/kg body weight/day) for 8 days, with a 2-week washout between the diets, were examined for within-subject differences in cognition, depression, mood, and headache. Measures included weight of foods consumed containing aspartame, mood and depression scales, and cognitive tests for working memory and spatial orientation. When consuming high-aspartame diets, participants had more irritable mood, exhibited more depression, and performed worse on spatial orientation tests. Aspartame consumption did not influence working memory. Given that the higher intake level tested here was well below the maximum acceptable daily intake level of 40–50 mg/kg body weight/day, careful consideration is warranted when consuming food products that may affect neurobehavioral health” (Lindseth et al., 2014, p. 185).

Relevant Study Results
“The mean age of the study participants was 20.8 years (SD = 2.5). The average number of years of education was 13.4 (SD = 1.0), and the mean body mass index was 24.1 (SD = 3.5). . . . Based on Vandenberg MRT scores, spatial orientation scores were significantly better for participants after their low-aspartame intake period than after their high intake period (Table 2). Two participants had clinically significant cognitive impairment after consuming high-aspartame diets. . . . Participants were significantly more depressed after they consumed the high-aspartame diet compared to when they consumed the low-aspartame diet (Table 2). . . . Only one participant reported a headache; no difference in headache incidence between high- and low-aspartame intake periods could be established” (Lindseth et al., 2014, p. 190).

TABLE 2

WITHIN-SUBJECT DIFFERENCES IN NEUROBEHAVIOR SCORES AFTER HIGH AND LOW ASPARTAME INTAKE (N = 28)

Variable M SD Paired t-Test p
Spatial orientation
High-aspartame 14.1 4.2 2.4 .03*
Low-aspartame 16.6 4.3
Working memory
High-aspartame 730.0 152.7 1.5 N.S.
Low-aspartame 761.1 201.6
Mood (irritability)
High-aspartame 33.4 9.0 3.4 .002**
Low-aspartame 30.5 7.3
Depression
High-aspartame 36.8 7.0 3.8 .001**
Low-aspartame 34.4 6.2
image

*p < .05.

**p < .01.

M = Mean; SD = Standard deviation; N.S. = Nonsignificant.

Lindseth, G. N., Coolahan, S. E., Petros, T. V., & Lindseth, P. D. (2014). Neurobehavioral effects of aspartame consumption. Research in Nursing & Health, 37(3), p. 190

Explain any difference between what you expected to achieve with Decision #2 and the results of the decision. Why were they different?

Therapy for Pediatric Clients With Mood Disorders

Mood disorders can impact every facet of a child’s life, making the most basic activities difficult for clients and their families. This was the case for 13-year-old Kara, who was struggling at home and at school. For more than 8 years, Kara suffered from temper tantrums, impulsiveness, inappropriate behavior, difficulty in judgment, and sleep issues. As a psychiatric mental health nurse practitioner working with pediatric clients, you must be able to assess whether these symptoms are caused by psychological, social, or underlying growth and development issues. You must then be able recommend appropriate therapies.

This week, as you examine antidepressant therapies, you explore the assessment and treatment of pediatric clients with mood disorders. You also consider ethical and legal implications of these therapies.

Photo Credit: GettyLicense_185239711.jpg

Assignment: Assessing and Treating Pediatric Clients With Mood Disorders

When pediatric clients present with mood disorders, the process of assessing, diagnosing, and treating them can be quite complex. Children not only present with different signs and symptoms than adult clients with the same disorders, but they also metabolize medications much differently. As a result, psychiatric mental health nurse practitioners must exercise caution when prescribing psychotropic medications to these clients. For this Assignment, as you examine the client case study in this week’s Learning Resources, consider how you might assess and treat pediatric clients presenting with mood disorders.

Note: This Assignment is the first of 10 assignments that are based on interactive client case studies. For these assignments, you will be required to make decisions about how to assess and treat clients. Each of your decisions will have a consequence. Some consequences will be insignificant, and others may be life altering. You are not expected to make the “right” decision every time; in fact, some scenarios may not have a “right” decision. You are, however, expected to learn from each decision you make and demonstrate the ability to weigh risks versus benefits to prescribe appropriate treatments for clients.

Learning Objectives

Students will:

Assess client factors and history to develop personalized plans of antidepressant therapy for pediatric clients

Analyze factors that influence pharmacokinetic and pharmacodynamic processes in pediatric clients requiring antidepressant therapy

Evaluate efficacy of treatment plans

Analyze ethical and legal implications related to prescribing antidepressant therapy to pediatric clients

Learning Resources

Note: To access this week’s required library resources, please click on the link to the Course Readings List, found in the Course Materials section of your Syllabus.

Required Readings

Note: All Stahl resources can be accessed through the Walden Library using this link. This link will take you to a log-in page for the Walden Library. Once you log into the library, the Stahl website will appear.

Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY: Cambridge University Press.

Note: To access the following chapters, click on the Essential Psychopharmacology, 4th ed tab on the Stahl Online website and select the appropriate chapter. Be sure to read all sections on the left navigation bar for each chapter.

Chapter 6, “Mood Disorders”

Chapter 7, “Antidepressants”

Stahl, S. M. (2014b). The prescriber’s guide (5th ed.). New York, NY: Cambridge University Press.

Note: To access the following medications, click on the The Prescriber’s Guide, 5th ed tab on the Stahl Online website and select the appropriate chapter. Be sure to read all sections on the left navigation bar for each chapter.

Review the following medications:

amitriptyline

bupropion

citalopram

clomipramine

desipramine

desvenlafaxine

doxepin

duloxetine

escitalopram

fluoxetine

fluvoxamine

imipramine

ketamine

mirtazapine

nortriptyline

paroxetine

selegiline

sertraline

trazodone

venlafaxine

vilazodone

vortioxetine

Magellan Health, Inc. (2013). Appropriate use of psychotropic drugs in children and adolescents: A clinical monograph. Retrieved from https://www.magellanprovider.com/media/11740/psychotropicdrugsinkids.pdf

Rao, U. (2013). Biomarkers in pediatric depression. Depression & Anxiety, 30(9), 787–791. doi:10.1002/da.22171

Note: Retrieved from Walden Library databases.

Vitiello, B. (2012). Principles in using psychotropic medication in children and adolescents. In J. M. Rey (Ed.), IACAPAP e-Textbook of Child and Adolescent Mental Health. Geneva: International Association for Child and Adolescent Psychiatry and Allied Professions. Retrieved from http://iacapap.org/wp-content/uploads/A.7-PSYCHOPHARMACOLOGY-072012.pdf

Poznanski, E., & Mokros, H. (1996). Child Depression Rating Scale–Revised. Los Angeles, CA: Western Psychological Services.

Note: Retrieved from Walden Library databases.

Required Media

Laureate Education (2016e). Case study: An African American child suffering from depression [Interactive media file]. Baltimore, MD: Author.

Note: This case study will serve as the foundation for this week’s Assignment.

Optional Resources

El Marroun, H., White, T., Verhulst, F., & Tiemeier, H. (2014). Maternal use of antidepressant or anxiolytic medication during pregnancy and childhood neurodevelopmental outcomes: A systematic review. European Child & Adolescent Psychiatry, 23(10), 973–992. doi:10.1007/s00787-014-0558-3

Gordon, M. S., & Melvin, G. A. (2014). Do antidepressants make children and adolescents suicidal? Journal of Pediatrics and Child Health, 50(11), 847–854. doi:10.1111/jpc.12655

Seedat, S. (2014). Controversies in the use of antidepressants in children and adolescents: A decade since the storm and where do we stand now? Journal of Child & Adolescent Mental Health, 26(2), iii–v. doi:10.2989/17280583.2014.938497

To prepare for this Assignment:

Review this week’s Learning Resources. Consider how to assess and treat pediatric clients requiring antidepressant therapy.

The Assignment

Examine Case Study: An African American Child Suffering From Depression. You will be asked to make three decisions concerning the medication to prescribe to this client. Be sure to consider factors that might impact the client’s pharmacokinetic and pharmacodynamic processes.

At each decision point stop to complete the following:

Decision #1

Which decision did you select? See below.

Why did you select this decision? Support your response with evidence and references to the Learning Resources.

What were you hoping to achieve by making this decision? Support your response with evidence and references to the Learning Resources.

Explain any difference between what you expected to achieve with Decision #1 and the results of the decision. Why were they different?

Decision #2

Why did you select this decision? Support your response with evidence and references to the Learning Resources.

What were you hoping to achieve by making this decision? Support your response with evidence and references to the Learning Resources.

Explain any difference between what you expected to achieve with Decision #2 and the results of the decision. Why were they different?

Decision #3

Why did you select this decision? Support your response with evidence and references to the Learning Resources.

What were you hoping to achieve by making this decision? Support your response with evidence and references to the Learning Resources.

Explain any difference between what you expected to achieve with Decision #3 and the results of the decision. Why were they different?

Also include how ethical considerations might impact your treatment plan and communication with clients.

BACKGROUND INFORMATION

The client is an 8-year-old African American male who arrives at the ER with his mother. He is exhibiting signs of depression.

Client complained of feeling “sad”

Mother reports that teacher said child is withdrawn from peers in class

Mother notes decreased appetite and occasional periods of irritation

Client reached all developmental landmarks at appropriate ages

Physical exam unremarkable

Laboratory studies WNL

Child referred to psychiatry for evaluation

Client seen by Psychiatric Nurse Practitioner

MENTAL STATUS EXAM

Alert & oriented X 3, speech clear, coherent, goal directed, spontaneous. Self-reported mood is “sad”. Affect somewhat blunted, but child smiled appropriately at various points throughout the clinical interview. He denies visual or auditory hallucinations. No delusional or paranoid thought processes noted. Judgment and insight appear to be age-appropriate. He is not endorsing active suicidal ideation, but does admit that he often thinks about himself being dead and what it would be like to be dead.

The PMHNP administers the Children’s Depression Rating Scale, obtaining a score of 30 (indicating significant depression)

RESOURCES

§ Poznanski, E., & Mokros, H. (1996). Child Depression Rating Scale–Revised. Los Angeles, CA: Western Psychological Services.

Decision Point One

Select what the PMHNP should do:

Begin Zoloft 25 mg orally daily

Begin Paxil 10 mg orally daily

Begin Wellbutrin 75 mg orally BID

Case Study of the above client

Decision Point One

I selected Zoloft 25 mg orally daily

RESULTS OF DECISION POINT ONE

Client returns to clinic in four weeks

No change in depressive symptoms at all

Decision Point Two

Increase dose to 50 mg orally daily

RESULTS OF DECISION POINT TWO

Client returns to clinic in four weeks

Depressive symptoms decrease by 50%. Cleint tolerating well

Decision Point Three

Maintain current dose

Guidance to Student

At this point, sufficient symptom reduction has been achieved. This is considered a “response” to therapy. Can continue with current dose for additional 4 week to see if any further reductions in depressive symptoms are noted. An increase in dose may be warranted since this is not “full” remission- Discuss pros/cons of increasing drug dose with client at this time and empower the client to be part of the decision. There is no indication that the drug therapy should be changed to an SNRI at this point as the client is clearly responding to this therapy