Biostatistics in healthcare

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Immune Responses Abnormal immune responses can trigger a range of autoimmune diseases, in which an individual’s immune system is attacking normal tissues in the body. Well-known examples of autoimmune diseases are type 1 diabetes mellitus, lupus, and multiple sclerosis. Ideally, one would like to harness the immune system to attack abnormal substances or tissues like cancer, while sparing the normal (unaffected) tissue. Many tumor cells produce antigens (proteins) that theoretically ought to trigger an immune response: that is, one’s immune system ought to recognize cancer cells as somehow foreign or abnormal, and thereafter eliminate these cells from the body. The field of cancer immunotherapy is actively pursuing this study. Tumor antigens may also be useful for diagnostic tests; high levels of tumor antigens could be taken as markers or indicators of cancer. In this assignment, you will be examining levels of tumor-associated antigens (TAAs) as determined from immunoassays (i.e., biochemical tests that measure the concentrations of the tumor-associated antigens in serum samples).

  • Download the Excel file MHA610_assignment_3_data.xls, and open it.
  • The spreadsheet contains data on 250 individuals: 90 normal individuals from San Diego (the controls), and 160 individuals from Korea and China, all of whom were diagnosed with hepatocellular carcinoma (HCC).
    • Serum samples were taken from the controls and from the cases at time of diagnosis of HCC. Levels of a panel of 12 tumor-associated antigens (TAAs) were assessed via immunoassays in all individuals;
      • The levels are given in the columns with headings Ab14, HCC1, IMP1, KOC, MDM2, NPM1, P16, P53, P90, RaIA, and Survivin. (These are the designations of the 12 TAAs, all of which were thought to be potentially predictive of cancer.)
  • The underlying question is whether we can effectively discriminate between the cases and controls on the basis of the levels of these TAAs. This is sometimes termed a classification problem in the statistics and biostatistics literature: we wish to classify individuals as normal or cancer patients on the basis of their TAA levels.
  • We will examine these data in Statdisk. Use the MHA610_Week 3_Assignment_Data.CSV file to upload this information into Statdisk.
    • If you choose the latter option, Start Statdisk, then choose File>Open and select the .csv file you created (unless you changed the name, it ought to be MHA610_assignment_3_data.csv)
    • Check the box that specifies the data contains column titles or headers, select Comma separated for how the data are delimited, click finish, and the dataset will have been successfully imported into Statdisk.
    • NOTE: you may want to read through the remainder of the assignment first, before proceeding with this step. This may save you some work afterwards!
  • Note that Statdisk operates on columns of data, and that both cases and controls are contained in each column of TAA levels. It will be necessary to separate the cases and controls for further analyses. This can be accomplished either by copying within Statdisk or by reverting to the original Excel workbook, copying in Excel, exporting as a .csv file, and then importing into Statdisk. (Don’t say you weren’t warned!)
  • Explain if you would characterize any or all of the TAA levels as approximately normally distributed for the controls and for the cases.
    • Provide plots and statistics in support of your conclusions.
  • Explain if any of the TAAs are useful for discriminating between the cases and controls.
    • Provide plots and statistics in support of your conclusions.
  • All writing assignments should be at least 250-500 words in APA format supported by scholarly sources.

BONUS. In the above, we pooled all cases together.  Summarize whether you think this is legitimate or whether the levels of any of the TAAs appear to differ significantly between the cases from China and the cases from Korea. Provide evidence in support of your conclusion.

ASSIGNMENT

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Due Date: Jun 9, 2017           Max Points: 150Details:

Write a 750-1000 word analysis of “Case Study: Fetal Abnormality.” Be sure to address the following questions:

  1. Which theory or theories are being used by Jessica, Marco, Maria, and Dr. Wilson to determine the moral status of the fetus? Explain.
  2. How does the theory determine or influence each of their recommendation for action?
  3. What theory do you agree with? How would that theory determine or influence the recommendation for action?

Prepare this assignment according to the guidelines found in the APA Style Guide, located in the Student Success Center. An abstract is not required.

This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.

You are required to submit this assignment to Turnitin. Please refer to the directions in the Student Success Center.

PHI-413V-RS-T2CaseStudy.docx

Case Study on Moral Status

Assignment Week 1 ,

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Read and summarize the article in 2- 2 1/2pgs (Microsoft Word, 12pt double spaced). You must include your personal thoughts about the article.

– What characteristics should a healthcare executive possess?

– How important is patient safety from a healthcare executive perspective?

– Why should staff engagement start at the top?

the artical on the item.. 

Case Study: Doctor shortage

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Review the article and answer the questions that are presented at the end of the case. You are required to seek a minimum of 2 external resources, for this assessment. Your final discussion should be professional, include detailed information, and be void of opinion. This assessment requires the use of FULL APA 6th ed. formatting. The use of APA level headings in this discussion will allow for organization and flow of discussion and is a recommended component.Consists of a minimum 650 words in the core discussion (excludes title page, abstract, running headers, reference page information)CASE STUDY #1 SYNOPSIS

According to the attached article “The Experts: What Should Be Done to Fix the Predicted U.S. Doctor Shortage?” (Links to an external site.) Published in the Wall Street Journal on June 20, 2013, What, if anything, should be done to alleviate the predicted doctor shortage in the U.S.? The Wall Street Journal put this question to The Experts, an exclusive group of industry, academic and other thought leaders who engage in in-depth online discussions of topics from the print Report.

CASE STUDY #1 DISCUSSION 1

  1. Is there a shortage of physicians overall, or only in key areas (both geographically and by specialty)?
  2. What are the key barriers to increasing the number of physicians (consider primary care and specialty physicians)?
  3. What policies might be used to address these issues?
  4. What can hospitals do to recruit and retain physicians? Consider recruitment tactics that are not misguiding (for example avoid tactics such as – new construction, new vision)
  5. What impact does physician-hospital integration and alignment have on the physician shortage?
  6. What impact does international medical programs have on the physician shortage?
  7. Using a table or chart include the projected physician shortages. Include a paragraph of discussion to explain your table or chart. (You may use a chart/table from a resource rather than create your own. Be sure to reference the tool correctly according to APA 6th ed. Chapter 5).
  8. Given the layered aspects of the physician shortage and the understanding that filling this gap reaches beyond the medical schools, what are some alternative strategies?
  9. Select one panel expert and choose to agree or disagree with their position on how to alleviate the physician shortage. Please include the panel expert’s name and position in your discussion.

Which symptoms are typical in people who have cancer? Check all that apply. resistance to insulin sores that do not heal onset of a gluten allergy recent change in a wart or mole thickenings or lumps

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Which symptoms are typical in people who have cancer? Check all that apply.

resistance to insulin

sores that do not heal

onset of a gluten allergy

recent change in a wart or mole

thickenings or lumps in an area of the body

Benchmark – Community Teaching Plan: Community Presentation

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 PLEASE FOLLOW EVERY INSTRUCTION. READ AND COMPLETE THE DOCUMENT ATTACHED BELLOW. 18 SLIDES OF THE  POWER POINT PRESENTATION

Details:

Note: This is an individual assignment. Based on the feedback offered by the provider, identify the best approach for teaching. Prepare a presentation to accompany the teaching plan and present the information to your community. Select one of the following options for delivery of the presentation:

  1. PowerPoint presentation – no more than 30 minutes
  2. Pamphlet presentation – 1 to 2 pages
  3. Poster presentation

Appropriate community settings include:

  • Public health clinic
  • Community health center
  • Long-term care facility
  • Transitional care facility
  • Home health center
  • University/School health center
  • Church community
  • Adult/Child care center

Before presenting information to the community, seek approval from an agency administrator or representative.

Upon receiving approval from the agency, include the “Community Teaching Experience Form” as part of your assignment submission.

APA format is required for essays only. Solid academic writing is always expected. For all assignment delivery options, documentation of sources should be presented using APA formatting guidelines, which can be found in the APA Style Guide, located in the Student Success Center.

You are not required to submit this assignment to Turnitin.

NRS-427V-RS-CommunityTeachingExperienceForm.doc

How is cardio exercise best described? It gives your heart and lungs a continuous workout. It does not require a continual oxygen supply. It requires short, intense bursts of energy. It lasts only min

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How is cardio exercise best described? It gives your heart and lungs a continuous workout. It does not require a continual oxygen supply. It requires short, intense bursts of energy. It lasts only minutes or seconds. NextReset

When teaching an unlicensed assistive personnel (UAP) new to the unit about the principles for the care of a client diagnosed with a personality disorder, the nurse should explain that: a. the staff

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When teaching an unlicensed assistive personnel (UAP) new to the unit about the principles for the care of a client diagnosed with a personality disorder, the nurse should explain that:

a. the staff members are the primary ones left to care about these clients.

b. clients need limits on their behavior.

c. the staff should use minimal humor when working with these clients.

d. the clients are accepted although their behavior may not be.

NURSING – DEATH AND DYING CASE STUDY

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DUE 7/11/2017 AT 9AM, BE SURE TO HAVE AN INTO THAT HAS A CLEAR THESIS STATEMENT AND CONCLUSION – SEE RUBRIC ATTACHMENT PRIOR TO START OF ASSIGNMENT

Details:

The practice of health care providers at all levels brings you into contact with people from a variety of faiths. This calls for knowledge and acceptance of a diversity of faith expressions.

The purpose of this paper is to complete a comparative ethical analysis of George’s situation and decision from the perspective of two worldviews or religions: Christianity and a second religion of your choosing. For the second faith, choose a faith that is unfamiliar to you. Examples of faiths to choose from include Sikh, Baha’i, Buddhism, Shintoism, etc.

In your comparative analysis, address all of the worldview questions in detail for Christianity and your selected faith. Refer to Chapter 2 of Called to Care for the list of questions. Once you have outlined the worldview of each religion, begin your ethical analysis from each perspective.

In a minimum of 1,500-2,000 words, provide an ethical analysis based upon the different belief systems, reinforcing major themes with insights gained from your research, and answering the following questions based on the research:

  1. How would each religion interpret the nature of George’s malady and suffering? Is there a “why” to his disease and suffering? (i.e., is there a reason for why George is ill, beyond the reality of physical malady?)
  2. In George’s analysis of his own life, how would each religion think about the value of his life as a person, and value of his life with ALS?
  3. What sorts of values and considerations would each religion focus on in deliberating about whether or not George should opt for euthanasia?
  4. Given the above, what options would be morally justified under each religion for George and why?
  5. Finally, present and defend your own view.

Support your position by referencing at least three academic resources (preferably from the GCU Library) in addition to the course readings, lectures, the Bible, and the textbooks for each religion. Each religion must have a primary source included. A total of six references are required according to the specifications listed above. Incorporate the research into your writing in an appropriate, scholarly manner.

Prepare this assignment according to the guidelines in APA Style Guide,

This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.

You are required to submit this assignment to Turnitin.